摘要
目的:探讨病毒性心肌炎(VM)患者血清巨噬细胞移动抑制因子(MIF)、白介素-6(IL-6)、白介素-8(IL-8)水平的变化及临床意义。方法:对确诊为VM的46例患者和正常对照组20例进行血清MIF、IL-6、IL-8、心肌肌钙蛋白I(cTnI)及磷酸肌酸激酶同工酶(CK-MB)浓度测定。结果:VM急性期血清MIF、IL-6、IL-8、cTnI、CK-MB浓度较VM恢复期及对照组显著升高(P<0.01),且VM急性期MIF、IL-6、IL-8与cTnI、CK-MB均呈正相关(P<0.05)。结论:MIF、IL-6、IL-8可能参与VM发病过程,并可作为病情判断及疗效的观察指标。
Objective: To investigate the change of serum macrophage migration inhibitory factor (MIF), interleukin-6(IL-6)and interleukin-8(IL-8) in patients with viral myocarditis (VM) and its clinical significance. Methods: The serum levels of MIF, IL-6, IL-8, cTnI and CK-MB were detected in 43 patients with VM and 20 normal healthy people as controls. Results: The serum levels of MIF, IL-6, IL-8, cTnI and CK-MB in VM group with the acute stage were higher than those of VM group with recovery stage and control group(P〈0.01)and there was positive correlation between M1F, IL-6, IL-8 and cTnl, CK-MB(P〈0.05). Conclusion: MIF, IL-6 and IL-8 may take part in the VM pathogenesis, and their can be a new indicator for VM.
出处
《中外医学研究》
2013年第2期32-33,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH