病毒性心肌炎患者血清巨噬细胞移动抑制因子、白介素-6、白介素-8水平的变化及意义

Change and Significance of Macrophage Migration Inhibitory Factor,Interleukin-6 and Interleukin-8 in Serum of Patients with Viral Myocarditis

目的:探讨病毒性心肌炎(VM)患者血清巨噬细胞移动抑制因子(MIF)、白介素-6(IL-6)、白介素-8(IL-8)水平的变化及临床意义。方法:对确诊为VM的46例患者和正常对照组20例进行血清MIF、IL-6、IL-8、心肌肌钙蛋白I(cTnI)及磷酸肌酸激酶同工酶(CK-MB)浓度测定。结果:VM急性期血清MIF、IL-6、IL-8、cTnI、CK-MB浓度较VM恢复期及对照组显著升高(P<0.01),且VM急性期MIF、IL-6、IL-8与cTnI、CK-MB均呈正相关(P<0.05)。结论:MIF、IL-6、IL-8可能参与VM发病过程,并可作为病情判断及疗效的观察指标。

Objective： To investigate the change of serum macrophage migration inhibitory factor （MIF）, interleukin-6（IL-6）and interleukin-8（IL-8） in patients with viral myocarditis （VM） and its clinical significance. Methods： The serum levels of MIF, IL-6, IL-8, cTnI and CK-MB were detected in 43 patients with VM and 20 normal healthy people as controls. Results： The serum levels of MIF, IL-6, IL-8, cTnI and CK-MB in VM group with the acute stage were higher than those of VM group with recovery stage and control group（P〈0.01）and there was positive correlation between M1F, IL-6, IL-8 and cTnl, CK-MB（P〈0.05）. Conclusion： MIF, IL-6 and IL-8 may take part in the VM pathogenesis, and their can be a new indicator for VM.