烫伤合剂对大鼠Ⅱ度烫伤创面的作用研究

Effects of tangshang mixture on Ⅱ degree scald wound in rats

目的研究烫伤合剂在大鼠Ⅱ度烫伤创面愈合过程中的作用。方法 80只SD大鼠随机分成空白对照组、模型对照组、阳性药物对照组和烫伤合剂组,通过烫伤后不同时间点创面取材,检测创面愈合率、创面组织新生毛细血管数量及创面羟脯氨酸含量。结果烫伤合剂组的创面愈合率、创面新生毛细血管数量和羟脯氨酸含量均高于对照组,差异有统计学意义(P<0.05)。结论烫伤合剂可促进Ⅱ度烫伤创面愈合,其作用机理可能与提升创面组织中新生毛细血管数量和羟脯氨酸含量有关。

Objective To study the effects of tangshang mixture on Ⅱ degree scald wound healing. Methods 80 SD rats were divided randomly into blank control group, model control group, positive drug group and tangshang mixture group. The wound tissue samples were harvested at different times for the determinations of healing rate , the number of new blood capillaries and hydroxyproline contents. Results Wound healing rate, the number of new blood capillaries and hydroxyproline contents of tangshang mixture group were higher than those of control groups respectively. The differences were statistically significance （P 〈 0. 05） . Conclusion Tangshang mixture could promote scald wound healing, which might be associated with the rise of new blood capillary and hydroxyproline content.