小剂量甲泼尼龙联合西咪替丁治疗腹型过敏性紫癜的临床观察

Clinical observation on the small dose of methylprednisolone combined with cimetidine in the treatment of abdominal type allergic purpura

目的:观察小剂量甲泼尼龙联合西咪替丁治疗腹型过敏性紫癜(HSP)的临床疗效。方法:选择2008年1月-2011年2月住院的腹型HSP患儿62例,随机抽签分为治疗组32例,对照组30例。所有患儿入院后均予常规综合治疗,治疗组在常规综合治疗的基础上,加用注射用甲泼尼龙琥珀酸钠每次1～2 mg.kg-1,bid,静滴,5 d为1个疗程,西米替丁每次10～20mg.kg-1静滴,bid。对照组在常规治疗的基础上,给予琥珀酸氢化可的松注射液每次5～10 mg.kg-1,bid静滴,连续5 d为1个疗程。观察两组呕吐停止、腹痛缓解、便血消失时间及平均住院天数。结果:治疗组呕吐停止、腹痛缓解、便血消失时间及平均住院天数均较对照组明显缩短,差异显著(P<0.05);总有效率治疗组为96.88%,对照组为76.67%。治疗期间患儿均未出现明显的药品不良反应。结论:小剂量甲泼尼龙联合西咪替丁治疗腹型HSP,可明显缓解各种症状,有效缩短病程。

OBJECWIVE To observe the curative effect of small dose of methylprednisolone combined with cimetidine in the treatment of abdominal type allergic purpura clinical. METHODS From January 2008 to February 2011,62 cases of HSP hospi talization of abdominal type were randomly divided into a treatment group of 32 cases and a control group of 30 cases. On the basis of comprehensive treatment, the conventional treatment group added metbylprednisolone sodium succinate for injection every time 1-2 mg/kg, 2/d IVGTT, 5D for 1 courses, each 10-20mg/kg cimetidine, 2/d after the admission of all the pa- tients to the routine treatment. On the basis of routine treatment, the control group gave bydrocortisone succinate injection in each 5-10 mg/kg, 2/d IVGTT, with continuous five days as a course of treatment, observing two groups of vomiting, ab- dominal pain, bloody stool stop disappearing time and average days of hospitalization. R^ULTS The relief of abdominal pain, vomiting stopped bleeding time and the mean hospital stay of the treatment group were significantly shorter than that of the control group. The difference was statistically significant （P〈 0. 05） and the total effective rate in treatment group was 96. 88 %, while 76. 67 %, During the treatment, there was no children showed obvious adverse drug reaction. CONCLUSION Small dose methylprednisolone combined with cimetidine, in treatment of abdominal type allergic purpura, can obviously relieve various symptoms and shorten the course of disease,