摘要
血管内皮生长因子(VEGF)及血管内皮生长因子受体-2(VEGFR-2)是调节血管生成、内皮细胞增殖和迁移等的关键调控因子。通过阻断VEGF与VEGFR-2的结合可抑制新生血管形成,而新生血管的形成是肿瘤生长和转移的基础。介绍VEGF/VEGFR-2在血管形成中的作用,以及具有抗肿瘤作用的靶向VEGF/VEGFR-2的血管生成抑制剂的研究近况。
Vascular endothelial growth factor （VEGF） and its tyrosine kinase receptor -- VEGFR-2 play the critical roles in modulating angiogenesis, as well as the proliferation and migration of endotbelium. Angiogenesis is a basis of tumor growth and metastasis. It is expected that blocking the interaction of VEGF and VEGFR-2 will be an efficient anticancer therapeutic approach. This review summarizes VEGF/ VEGFR-2 signaling related to angiogenesis, and the development of VEGF/VEGFR-2 inhibitors, including biomacromolecules and micromolecules.
出处
《药学进展》
CAS
2013年第1期8-16,共9页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金(No.81102364
No.81072561)
2011年国家级大学生实践创新训练项目
关键词
血管内皮生长因子
血管内皮生长因子受体-2
血管生成抑制剂
抗肿瘤
vascular endothelial growth factor
vascular endothelial growth factor receptor-2
anti-angiogenesis drug
antitumor
