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SphK／S1P信号通路与糖尿病肾病 被引量：3

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摘要 糖尿病肾病（diabetic nephropathy,DN）作为糖尿病的一个重要微血管并发症，是终末期肾病的首要病因，多种因素参与其发生与发展。近年来发现高血糖可以刺激肾脏的SphK／S1P信号通路，通过MAPK、Smads、PKC、Rho家族的小GTPases的激活，从而引起系膜细胞的增殖和系膜基质（extracellular matrix．ECM））的累积，导致肾脏的纤维化，而通过对该通路的选择性干预可延缓DN的进展，为DN提供新的治疗措施。
作者 雷莎(综述) 王秋月(审校)
机构地区 沈阳中国医科大学第一医院
出处 《国际泌尿系统杂志》 2013年第1期84-89,共6页 International Journal of Urology and Nephrology
关键词 糖尿病肾病 信号传递
分类号 R587.24 [医药卫生—内分泌]
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参考文献28

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  • 4Takabe K, Paugh SW, Milstien S, et al. " Inside- out" signaling of sphingosine - 1 - phosphate: therapeutic targets. Pharmacol Rev, 2008, 60(2): 181 -195.
  • 5Geoffroy K, Troncy L, Wiernsperger N, et ah Glomerular prolifer- ation during early stages of diabetic nephropathy is associated with local increase of sphingosine - 1 - phosphate levels. FEBS Lett, 2005, 579(5 ) : 1249 - 1254.
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同被引文献60

  • 1王耀献,刘尚建,赵宗江,吕仁和.肾炎防衰液对单侧输尿管梗阻性肾衰大鼠的治疗作用[J].中国中药杂志,2005,30(10):796-798. 被引量：17
  • 2李庆芳,吴祖泽.鞘氨醇激酶信号途径与血液肿瘤[J].中国实用内科杂志：临床前沿版,2006,26(3):401-403. 被引量：7
  • 3王颖航,王耀献,赵宗江,杨美娟.肾炎防衰液对5/6肾切除大鼠肾组织FN表达的影响[J].北京中医药大学学报,2007,30(6):409-412. 被引量：17
  • 4Obinata H, Hla T. Sphingosine-1-phosphate in coagulation andinflammation[J]. Semin Immunopathol, 2012, 34(1): 73-91.
  • 5Liu H, Sugiura M, Nava VE, et al. Molecular cloning and functionalcharacterization of a novel mammalian sphingosine kinase type 2isoform[J]. J Biol Chem, 2000, 275(26): 19513-19520.
  • 6Camerer E, Regard JB, Cornelissen I, et al. Sphingosine-1-phosphatein the plasma compartment regulates basal and inflammation-inducedvascular leak in mice[J]. J Clin Invest, 2009, 119(7): 1871-1879.
  • 7Takabe K, Paughs W, Milstien S, et al. “Inside-out” signaling ofsphinggosine-1-phosphate: therapeutictarget[J]. Pharmacol Rev,2008, 60(2): 181-195.
  • 8Satirapoj B. Nephropafhy indiabetes[J]. Adv Exp Med Biol, 2012,771: 107-122.
  • 9Jiang Q, Liu P, Wu X, et al. berberine attenuates lipopolysaccharideinducedextracelluar matrix accumulation and inflammation in ratmesangial cells: involvement of NF-kappaB signaling pathway[J].Mol Cell Endocrinol, 2011, 331(1): 34-40.
  • 10Geoffroy K, Troncy L, Wiernsperger N, et al. Glomerularproliferation during early stages of diabetic nephropathy is associatedwith local increase of sphingosine-1-phosphate levels[J]. FEBS Lett,2005, 579(5): 1249-1254.

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国际泌尿系统杂志
2013年 第1期

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