汉族人染色体12p13上的单核苷酸多态性rs12425791与中风中医证型的关联研究

Correlation Study on 12p13 Single Nucleotide Polymorphism rs12425791 and Chinese Medical Syndrome Types in Ischemic Stroke Patients of the Han Nationality

目的探讨汉族人染色体12p13上的单核苷酸多态性rs12425791与中风中医证型的相关性。方法采用病例对照研究方法,纳入148例汉族中风患者(痰浊证67例、血瘀证81例),另设192名健康人作对照,并采用TaqMan基因分型技术对rs12425791进行基因分型,分析基因分布及等位基因的分布频率。结果汉族人rs12425791的基因型、等位基因在中风痰浊证与对照组之间、中风血瘀证与对照组之间的分布比较,差异均无统计学意义(P>0.05)。结论该项研究结果不支持汉族人染色体12p13上的rs12425791与中风痰浊证、血瘀证的发病相关联。

Objective To explore the correlation between 12p13 single nucleotide polymorphism （SNP）rs12425791 and Chinese medical syndrome types of ischemic stroke patients of the Han nationality. Methods A case-control study was used. Recruited were 148 ischemic stroke patients of the Han nationality （67 patients of phlegm syndrome and 81 patients of blood stasis syndrome）. Another 192 healthy subjects were recruited as the control group. The genotypes of rs12425791 were performed by TaqMan SNP genotyping assays to analyze the distribution of genes and the distribution frequency of alleles. Re- sults There was no statistical difference in the genotype and alleles of rs12425791 between the ischemic stroke patients of phlegm syndrome and the control group, or between the ischemic stroke patients of blood stasis syndrome and the control group （P 〉0.05）. Conclusion Our results did not support that 12p13 common variant rs12425791 was correlated with the pathogeneses of ischemic stroke patients of phlegm syndrome and ischemic stroke patients of blood stasis syndrome.