上海市浦东新区丙型肝炎病毒感染危险因素的病例对照研究

Case-Control Study on Risk Factors for Hepatitis C Virus Infection in Pudong New Area,Shanghai

[目的]了解上海市浦东新区丙型肝炎病毒感染的主要危险因素,为控制该区丙型肝炎疫情提供科学依据。[方法]以2008—2009年该区传染病网络直报的109例丙型肝炎病例为研究对象,采用1∶1病例对照研究方法,调查其一般人口学特征和感染危险因素接触情况。应用单因素和多因素logistic回归分析危险因素。[结果]丙型肝炎病毒感染的危险因素,单因素分析结果为输血/血制品、手术治疗、修面/刮胡须和修脚史,多因素分析结果为创伤性美容和修面/刮胡须史。[结论]接受创伤性治疗及接触共用器具是丙型肝炎病毒感染的主要危险因素。应通过加强血制品管理、提高人群对共用器具危险性认识等综合性措施开展丙型肝炎防控工作。

[ Objective ] To identify major risk factors of hepatitis C virus infection in Pudong New Area in order to provide scientific evidence for the control of hepatitis C. [ Methods ] During 2008-2009, 109 individuals infected with hepatitis C virus included in Network Direct Report System of Infectious Disease Epidemics of Pudong New Area were interviewed about demographic characteristics and exposures to risk factors, with an equal number of controls, pair matched to cases by gender, age, and location. Univariate and multivariate logistic regression methods were used to analyze the risk factors for hepatitis C infection. [ Results ] The univariate analysis results showed that hepatitis C virus infection was associated with blood transfusion, operation history, shave, and pedicure. The multivariate analysis results showed that operative cosmesis and shave were risk factors for hepatitis C infection. [ Conclusion ] Operative cosmesis and exposures to sharing equipment are the risk factors for hepatitis C virus infection in Pudong New Area. More efforts should be directed towards management of blood products and improvement of people＇s awareness of the risk of sharing equipment to prevent hepatitis C infection.