杂多酸季铵盐双活性中心抗菌剂的合成及抑菌性能研究

Synthesis and Antibacterial Property of Heteropoly Acid Quaternary Ammonium Salt Antimicrobial Agent with Double Active Center

本文采取立体选择法合成以过渡元素V、Fe、Co和Ni为取代原子的Keggin结构的取代型磷钼杂多酸盐．在水热条件下与十二烷基三甲基溴化铵进行化合，得到了4种新的基于Keggin型多酸阴离子和季铵阳离子的复合物。通过红外（FT—IR）、紫外（UV—Visible）、热重（TG）、X射线衍射（XRD）、扫描电镜（SEM）、透射电镜（TEM）等手段进行了结构表征，并采用抑菌圈法对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌进行了抑菌活性研究。结果表明，所合成的复合物的分解温度较季铵盐提高了200℃：复合物的抑菌效果是季铵盐的2～3倍。

Phosphomolybdic heteropolyacid salt with Keggin structure with transition elements V, Fe, Co and Ni as substituted atom were synthesized by the stereoselective synthesis method. Four new Keggin type complexes with polyoxoanions and quaternary ammonium cation were obtained from phosphormolybdic heteropolyacid salt and dodecyltrimethylammonium bromide under hydrothermal condition. The structures of all the polyoxoanions and organic composite were characterized by the infrared （FT-IR） spectra, the ultraviolet visible （UV-Visible） spectra, thermogravimetry （TG）, X-ray diffraction （XRD）, scanning electron microscopy （SEM）, transmission electron microscopy （TEM）. The antibacterial activities of composite were tested for staphylococcus aureus, bacillus subtilis and escherichia coli by the inhibition zone method. The results indicated that the complexes have higher decomposition temperature than quaternary ammonium salt with 200℃ increment. The antibacterial activities of complexes is 2-3 times of quaternary ammonium salt.