摘要
目的检测NapsinA、TTF-1、CK5/6、CK7及P63在非小细胞肺癌(NSCLC)支气管镜活检标本中的表达及意义。方法采用免疫组织化学SP法检测47例NSCLC支气管镜活检标本中NapsinA、TTF-1、CK5/6、CK7及P63的表达,并结合NSCLC的临床特征病理进行分析。结果 NapsinA、TTF-1和CK7在27例肺腺癌中的阳性表达率分别为100%(27/27)、100%(27/27)和93%(25/27),表达水平明显高于CK5/6[19%(5/27)]和P63[0(0/27)](P<0.05);而CK5/6和P63在18例肺鳞癌中的阳性率均为100%(18/18),表达水平明显高于NapsinA及TTF-1[0(0/18)、0(0/18)]和CK7[11%(2/18)](P<0.05),两者差异均具有统计学意义。结论 NapsinA、TTF-1、CK7、CK5/6及P63在肺支气管镜活检标本腺癌和鳞癌鉴别诊断中具有重要意义。
Objective To detect the expression and significance of NapsinA, TTF-1, CK5/6, CK7 and P63 in biopsy specimen by bronchoseope of non-small cell lung cancer（NSCLC）. Methods The expressions of N apsinA,TTF-1 ,CKS/6,CK7 and P63 were detected by immunohistoehemical SP method in 47 N SCLC of biopsy specimen by bronchoscope,and the clinicalpathologieal features of NSCLC were analyzed statis tically. Results The positive rates of NapsinA,TTF 1 and CK7 were 100% （27/27）, 100% （27/27） and 93 % （25/27） in 27 cases of lung adenocarcinoma, respectively which was higher than CK5/6 19% （5/27） and P63 0（0/25）（P〈C0.05） ,respectively. The positive rates of CK5/6 and P63 were all 100%（18/18） in l 8 cases of lung squamous cell carcinoma, respectively which was higher than NapsinA 0 （0/18）, TTF 1 0 （0/18） and CK7 11 %%4 （2/18）（P〈0.05）, respectively. Both showed significant increasing gradient. Con- clusion NapsinA,TTF 1,CK5/6,CK7 and P63 expressions are important significance at the differential diagnosis between lung squamous cell carcinoma and adnocarcinoma in biopsy specimen by nchoscope.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2013年第1期76-78,共3页
Cancer Research on Prevention and Treatment
