炎症在结直肠癌发生中的作用机制

Role of inflammation in the carcinogenesis of colorectal cancer

结直肠癌是最常见的恶性肿瘤之一。流行病学和分子生物学研究表明炎症和结直肠癌发病之间存在着密切联系。目前关于炎症和结直肠癌发病有关的分子机制研究已有不少报道,但是尚不能完全阐释。若能发现结直肠癌发病的重要炎症基础,则可能为结直肠癌的预防和治疗提供新靶点。本文系统地对结直肠癌发病相关的炎症机制进行综述,以期为以后的进一步研究提供线索。

Colorectal cancer is one of the most common malignant tumors. Previous epidemiological and molecular biological studies have suggested that inflammation plays a pivotal role in the pathogenesis of colorectal cancer. Moreover, many studies have been focused on molecular pathways of inflammation in colorectal cancer. However, the explicit mechanisms involved remain to be fully elucidated. The identification of the key inflammatory mechanisms may provide new targets for intervention and treatment of colorectal cancer. Here we reviewed the inflammatory mechanisms relevant to the carcinogenesis of colorectal cancer, hoping to cast new lights on future research.