成纤维细胞生长因子21与2型糖尿病合并非酒精性脂肪肝关系的研究

Relationship between FGF-21 and type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease

采用酶联免疫吸附法检测2型糖尿病合并非酒精性脂肪肝（NAFLD）患者血中成纤维细胞生长因子21（FGF-21）水平，结果显示，2型糖尿病合并NAFLD患者的血清FGF-21水平高于单纯2型糖尿病患者[（266．55±21．24对220．32±22．68）ng/L，P〈0．01]，且2组均高于正常对照组[（173．52±16．18）ng/L，P〈0．01]。血清FGF-21水平与腰围、血糖、甘油三酯等呈正相关。FGF-21可能在2型糖尿病患者合并非酒精性脂肪肝的发生发展中发挥作用。

The level of serum fibroblast growth factor-21 （ FGF-21 ） in patients with type 2 diabetesmellitus complicated with non-alcoholic fatty liver disease （ NAFLD ） was determined by ELISA. The results showed that serum FGF-21 level in these patients was higher than that in type 2 diabetic patients [ （266.55 ± 21.24 vs 220.32 ± 22.68 ） ng/L,P〈0.01 ]. Serum FGF-21 levels in both groups were significantly higher than that in normal control group [ （ 173.52 ± 16.18） ng/L,P〈0. 01 ]. Serum FGF-21 level was positively correlated with waist circumference, blood glucose, and triglyceride. FGF-21 may contribute to the development of NAFLD in the patients with type 2 diabetes mellitus.