前蛋白转化酶枯草溶菌素9在绝经前后女性中的差异

Difference in proprotein convertase subtilisin/kexin type 9 levels between premenopausal and postmenopausal women

目的探讨前蛋白转化酶枯草溶菌素9（PCSK9）在绝经前和绝经后女性中的差异及其与代谢因素的相关性。方法从2009年参加南京2型糖尿病预测、预防、干预研究调查人群中随机抽取515名女性，收集空腹血样本，并对人选者进行问卷调查、体格检查及代谢相关指标的测定，用酶联免疫吸附法检测血清PCSK9水平。结果在女性人群中血清PCSK9水平与低密度脂蛋白胆固醇（LDL—C）、总胆固醇（TC）、甘油三酯、空腹血糖、体重指数、腰臀比、年龄呈正相关（均P〈0．01），绝经前女性的PCSK9水平显著低于绝经后的女性[（58．18±25．44对80．91±33．74）ng／ml，P〈0．01]。结论绝经前女性的PCSK9水平低于绝经后女性，且PCSK9水平与年龄、TC、LDL—C密切相关。

Objective To compare proprotein convertase subtilisin/kexin type 9 （PCSK9） levels between premenopausal and postmenopausal women, and to investigate the relationship between serum PCSK9 and metabolic factors. Methods Totally 515 women were enrolled from the study on diabetes of prediction, prevention, and intervention in Nanjing in 2009. Survey, physical examinations, and determination of related metabolic indexes were performed. Serum PCSK9 level was measured by sandwich ELISA. Results Serum PCSK9 level was positively correlated with low density lipoprotein-cholesterol （ LDL-C ）, total cholesterol （ TC ）, triglyceride, fasting plasma glucose, body mass index, waist-hip ratio, and age in women （ all P〈0.01 ）. PCSK9 level was significantly lower in premenopausal women than that in postmenopausal women [ （ 58. 18 ±25. 44 vs 80. 91 ± 33. 74 ） ng/ml, P 〈 0.01 ]. Conclusion Higher level of PCSK9 exists in postmenopausal women compared with premenopausal women. The level of PCSK9 is closely correlated with age, TC, and LDL-C.