摘要
棘皮动物微管相关类蛋白4(EML4)与间变性淋巴瘤激酶(ALK)融合基因首次被发现存在于部分非小细胞肺癌中。该融合基因是由2号染色体上2区1带和2区3带易位形成,可以诱导肿瘤生成,而ALK抑制剂能够拮抗其促肿瘤生成活性。本文旨在介绍EML4-ALK基因阳性表达肺癌患者的临床特征及该基因在肺癌诊断、治疗中的意义。
The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase(EML4-ALK) fusion gene resulting from the chromosome inversion inv (2) (p21 ;p23 ) recently was identified in non-small cell lung cancer. EML4-ALK fusion gene is oncogenic, which could be suppressed by ALK-inhibitor through blocking the downstream signaling pass-way of EML4-ALK. This re view will focus on the clinicopathologic characteristics and targeted therapy of EML4-ALK in lung cancer.
出处
《临床肿瘤学杂志》
CAS
2013年第1期78-81,共4页
Chinese Clinical Oncology
基金
国家自然科学基金资助项目(81000980)
江苏省卫生科研资助项目(H200968)