摘要
C/EBPα是转录因子C/EBP家族的重要成员,具有促进细胞分化、抑制组织细胞增殖的功能。最近的研究表明,在一些类型的肿瘤中C/EBPα作为抑癌基因而导致细胞分化紊乱和细胞周期停滞。该文对C/EBPα基因在肿瘤组织中的作用及研究进展作一综述。
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2013年第1期68-70,共3页
Chinese Journal of Clinical and Experimental Pathology
基金
国家自然科学基金(30860302、30660193)
国际合作与交流专题项目(2010DFB34100)
参考文献28
-
1House J S,Zhu S,Ranjan R. C/EBPalpha and C/EBPbeta are required for sebocyte differentiation and stratified squamous differentiation in adult mouse skin[J].PLoS One,2010,(03):e9837.
-
2Suh H C,Gooya J,Renn K. C/EBP alpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation[J].Blood,2006,(11):4308-4316.
-
3Hankey W,Silver M,Sun B S. Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBPα) p42 versus p30 may contribute in part,to aberrant C/EBPα activity in acute leukemias[J].Hematol Rep,2011,(01):e5.
-
4Gery S,Tanosaki S,Bose S. Down-regulation and growth inhibitory role of C/EBPA in breast cancer[J].Clinical Cancer Research,2005,(09):3184-3190.
-
5Johansen L M,Iwama A,Lodie T A. c-Myc is a critical target for c/EBPa in granulopoiesis[J].Molecular and Cellular Biology,2001,(11):3789-3806.
-
6Loomis K D,Zhu S,Yoon K. Genetic ablation of CCAAT/enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis[J].Cancer Research,2007,(14):6768-6776.
-
7Wu Y L,Zhou H C,Chen G Q. Molecular mechanisms of leukemia-associated protein degradation[J].Front Med China,2010,(04):363-370.
-
8Pulikkan J A,Denqler V,Peramanqalam P S. Cell cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia[J].Blood,2010,(09):1768-1778.
-
9Pulikkan J A,Peramangalam P S,Dengler V. C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations[J].Blood,2010,(25):5638-5649.
-
10Dedhia P H,Keeshan K,Sacha U J. Differential ability of tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia[J].Blood,2010,(08):1321-1328.
同被引文献17
-
1Jemal A,Bray F,Center MM,et al.Global cancer statistics [ J ].CA Cancer J Clin, 2011,61 (2) : 69-90.
-
2Siegel R, Naishadham D, Jemal A.Cancer statistics [ J ].CA Cancer J Clin, 2013,63 ( 1 ) : 11-30.
-
3Shaukat A, Mongin S J, Geisser MS, et al.Long-term mortality after screening for colorectal cancer[J].N Engl J Med, 2013,369(12) : 1106-1114.
-
4陆再英,钟南山,赵磊内科学[M].第7版.北京:人民卫生出版社,2009:420-421.
-
5Schuster MB,Porse BT.C/EBPalpha: a tumour suppressor inmultiple tissues [J].Biochim Biophys Acta,2006,1766( 1 ): 88-103.
-
6Tan EH, Hooi SC, Laban M, et al.CCAAT/enhancer binding protein alpha knock in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcino- ma[ J ].Cancer Res, 2005,65 (22) : 10330-10337.
-
7Chen Y,Costa RM,Love NR,et al.C/EBP alpha initiates primitive myelopoiesis in pluripotent embryonic cells [J]. Blood, 2009,114( 1 ) : 40-48.
-
8McFie PJ,Wang JL,Timchenko NA,et al.Identification of a corepressor that inhibits the transcriptional and growth ar- rest activities of CCAAT/enhancer binding pr -otein ct[ J ].J Biol Chem,2006,281(26) : 18069-18080.
-
9Fukuehi Y, Shibata F, Ito M, et al.Comprehensive analysis of myeloid lineage conversion using mice expressing an in- ducible form of C/EBP alpha[J ].EMBO J, 2006,25 (14) : 3398-3410.
-
10Reddy SD,Pakala SB,Ohshiro K,et al.MicroRNA 661,a C/EBPct target,inhibits metastatic tumor antigen 1 and regulates its functions [ J ]. Cancer Res, 2009,69 ( 14 ) : 5639-5642.
-
1龙海晨,王红英,李玉华,杨昕,左强强,范佩文,郭彩丽,潘泽民.新疆维吾尔族宫颈癌组织中C/EBPα第一外显子突变与HPV16感染的关系[J].石河子大学学报(自然科学版),2014,32(3):325-329. 被引量:3
-
2李瑶琛,李士瑛.甲状腺肿瘤cyclin E蛋白与PCNA的表达特点及相关性[J].山西职工医学院学报,1999,9(4):2-4.
-
3康华丽,杨昕,李玉华,左强强,龙海晨,李星,刘引引,潘泽民.C/EBP_α基因对维吾尔族宫颈鳞癌组织细胞增殖的影响[J].中华实用诊断与治疗杂志,2013,27(7):639-641. 被引量:1
-
4姬文灿,丁凯阳,朱薇波,汪健,张磊,吴竞生.骨髓增生异常综合征患者c/ebpα基因表达水平及其临床意义[J].中国实验血液学杂志,2011,19(1):90-93. 被引量:1
-
5杨金瑞,黄循,杨竹林.前列腺增生和前列腺癌组织细胞凋亡及Bcl-2、Bax基因表达的研究[J].中华泌尿外科杂志,2000,21(8):485-487. 被引量:23
-
6郭静,李冰琳,王琰.TGF-β1在宫颈鳞状细胞癌及其细胞外基质中的表达及其与PCNA的关系[J].陕西医学杂志,2008,37(12):1646-1649. 被引量:1
-
7董必文,段凤英,段训凰.5-氮-2′-脱氧胞苷联合曲古抑菌素A对人肺腺癌细胞株A549增殖和凋亡的影响[J].第三军医大学学报,2010,32(17):1857-1860. 被引量:2
-
8刘雪娜,孙成铭.转录因子C/EBPα和SOX4在白血病中的研究进展[J].现代肿瘤医学,2016,24(20):3303-3306. 被引量:2
-
9董必文,段凤英.5-aza-dC、TSA联合MeCP2的RNA干扰质粒对人肺腺癌细胞株A549生物学行为的影响[J].实验与检验医学,2010,28(2):110-113. 被引量:1
-
10赵晋梅,王宏伟,徐智芳,朱镭,白波,葛晓燕.急性髓系白血病患者转录因子CCAAT/增强子结合蛋白α基因突变研究[J].中华血液学杂志,2005,26(5):299-302. 被引量:1