新型纳米SiC无纺布生物安全性的初步评价

Preliminary biological assessment of a new nano-SiC fiber cloth

目的:初步评价新型纳米SiC无纺布的生物安全性,为其后期应用于口腔复合材料的研发提供相关生物学依据。方法:采用口腔黏膜刺激试验、急性全身毒性试验和溶血试验对新型纳米SiC无纺布进行生物安全性评价。结果:新型纳米SiC无纺布对实验家兔的口腔黏膜没有刺激性,对实验小鼠无急性全身毒性,溶血率为0.47%,符合医用要求,不会引起溶血现象。结论:新型纳米SiC无纺布显示了良好的生物相容性,为进一步开发口腔复合材料的应用提供了生物安全性依据。

Objective：to evaluate the biological security of the new nano-SiC fiber cloth for the development of dental composite material.Method：three tests were designed and carried out to assess the nano-SiC fiber cloth,including oral mucous membrane irritation test,urgent systemic toxicity test,hemolytic test.Result：there was not stimulation effect of oral mucosal membrane observed on rabbits,no urgent systemic toxicity effect reflected on rats,the hemolysis index was 0.47 %,no hemolytic effect.Conclusion：the new nano-SiC fiber cloth material exhibited satisfactory biological safety for clinical trial.