国人精确放疗联合经肝动脉化疗栓塞术治疗原发性肝癌疗效的Meta分析

Interventional treameant for primary hepatocellular carcinoma: A Meta-analysis of precision radiotherapy combined transcatheter arterial chemoembolization

目的:比较精确放疗联合经肝动脉灌注化疗栓塞治疗原发性肝癌与单纯经肝动脉灌注化疗栓塞治疗的疗效。方法:通过计算机和手工检索全面收集国内关于精确放疗联合经肝动脉灌注化疗栓塞与单纯经肝动脉灌注化疗栓塞治疗原发性肝癌的临床对照研究文献,并按Cochrane协作网推荐的方法进行Meta分析。采用RevMan 5.0软件,应用固定效应模式分析,对符合纳入标准的12个研究进行Meta分析。结果:与单纯经肝动脉灌注化疗栓塞相比,精确放疗联合经肝动脉灌注化疗栓塞治疗原发性肝癌,肿瘤有效率与控制率均有明显提高,远期生存率亦有明显提高,两者间差异有显著性。结论:精确放疗联合经肝动脉灌注化疗栓塞治疗原发性肝癌疗效好,安全性高,值得推广。

Objective：To compare the therapeutic effects of precision radiotherapy （PT） combined transcatheter arterial chemoembolization（TACE） and TACE alone for primary hepatocellular carcinoma. Methods： All data of patients with primary hepatocellular carcinoma underwent PT ＋ TACE versus TACE were collected from literature by electronic searching and handwork searching. Meta -analysis that recommended by Cochrane Collaboration was done for the data above, 12 researches enrolled in criteria were included in this study using RevMan 5.0 through fxed - effect model. Results： Compared with that of TACE alone, tumour therapeutic response rate and control rate in those underwent PT ＋ TACE was statistically higher, and the overall survival of PT ＋ TACE group also higher than TACE group,there were difference between two groups （ P 〈 0. 05 ）. Conclusion： Precision radiotherapy combined transcatheter arterial chemoembolization is feasible in patients of primary hepatocellular carcinoma.