多柔比星导致急性心肌毒性患者血中缺血修饰白蛋白的变化

Doxorubicin induced acute myocardial toxicity in patients with ischemia modified albumin

目的:探讨缺血修饰白蛋白(IMA)对多柔比星导致急性心肌毒性反应诊断的临床意义。方法:选取用多柔比星治疗发生急性心肌毒性反应的25例患者作为观察组,选取25名用多柔比星未发生心肌毒性反应的患者25名作为对照组,在10min、1、2、3、6h检测两组患者血清IMA值指标变化,对两组各个时间点IMA均数±标准差进行分析。结果:两组间各时间点血清IMA均数±标准差之间存在差异,有统计学意义(P<0.05),多柔比星导致的急性心肌毒性反应早期,其血清的IMA值就开始升高。结论:多柔比星导致的急性心肌毒性早期IMA就开始增高,而正常人群不会增高。

Objective：To study the clinical significance ischemia modified albumin on doxorubicin resulted in acute myocardial toxicity reaction. Methods：Selected 25 doxorubicin therapy acute myocardial toxicity patients as observation group ,25 with doxorubicin without myocardial toxicity 25 patients as controls. In 10min, 1,2,3,6h measured serum IMA indices. Results： Between the two groups at each time point of serum IMA mean were different （ P 〈 0. 05 ）. Doxorubicin caused acute myocardial toxicity response in the early stage. Conclusion：Doxorubicin induced acute myocardial toxicity at the early stage of IMA.