瘦素与CD105在胶质瘤组织中的表达及其相关性研究

Expressions of leptin and CD105 in human gliomas tissues and relationship between them

目的观察脑胶质瘤组织中瘦素和CD105的表达情况及其相关性,并探讨其意义。方法采用免疫组织化学染色法检测54例不同级别的脑胶质瘤组织及14例正常脑组织中瘦素与CD105的表达。结果正常脑组织中未检测到瘦素与CD105的表达。胶质瘤组织中瘦素和CD105的阳性表达率分别为75.93%和81.48%,且胶质瘤病理级别与二者的表达呈明显正相关(P<0.01);胶质瘤组织中瘦素与CD105表达呈正相关(P<0.01)。结论瘦素可能参与了脑胶质瘤的发展,并可促进肿瘤组织中新生血管的生成。

Objective To study the expressions of leptin and CD105 in human glioma tissues and their meanings. Methods The expressions of leptin and CD105 in 54 specimens of human gliomas tissues, of which, 8 belonged in WHO grade Ⅰ , 14 in gradeⅡ, 15 in grade Ⅲ and 17 in grade Ⅳ, and in 14 specimens of the normal brain tissues were determined by immunohistochemical method. Results There is not the expressions of leptin and CD105 in the normal brain tissues. The positive expression rates of leptin and CD105 were 75.93% and 81.48% respectively in the glioma tissues. The expressions of leptin and CD105 in the gliomas tissues were positively related to WHO grades of the gliomas （P〈0.01）. There is a positive relationship between the expressions of leptin and CD105 in the gliomas tissues （P〈0.01）. Conclusion It is suggested that leptin may participate in the pathological development of the gliomas, and promote the formation of new blood vessels in the glioma tissues.