肿瘤坏死因子α-238G/A基因多态性对轻度认知功能障碍的影响

Effect of tumor necrosis factor-α-238G/A gene polymorphism on mild cognitive impairment

目的探讨肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)-238G/A基因多态性对轻度认知功能障碍(mild cognitive impairment,MCI)的影响。方法选择MCI患者100例,非MCI的正常人112名,应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法检测TNF-α-238G/A的基因多态性。结果 MIC组与对照组TNF-α-238G/A基因型频率与等位基因频率的分布比较,差异无统计学意义(P>0.05)。结论 TNF-α-238G/A基因多态性对MCI的影响不明显。

Objectives To investigate the effect of tumor necrosis factor-α （TNF-α） -238G/A gene polymorphism on mild cognitive impaimmnt （MCI）. Methods Totally 100 MCI patients and 112 normal controls were selected for this study. The gene polymorphism of TNF-α-238G/A was detected by polymerase chain reaction-restriction fragment length polymolphism （PCR-RFLP）. Results The genotypic frequency and allele frequency of TNF-α-238G/A had no significant differences between MCI group and control group （P〉0.05）. Conclusions There is no significant effect of TNF-α-238G/A gene polymorphism on MCI.