平谷区医院2007—2011年血流感染病原学特点及耐药性分析

Characteristics and Drug Resistance Analysis of Blood Stream Infection Nosazontology in Pinggu District Hospital during 2007—2011

目的调查血流感染(blood stream infection,BSI)的病原菌种类和耐药特点,为临床诊断和治疗提供依据。方法回顾性分析我院2007—2011年BSI的病原菌种类及对常用抗菌药物的敏感性。结果 2007—2011年对可疑BSI行血培养共3107份,阳性416份(13.4%)。在所分离的病原菌中,革兰阴性菌229株(55.0%),革兰阳性菌180株(43.2%),真菌6株(1.4%),厌氧菌1株(0.2%)。排名前五位的病原菌依次是大肠埃希菌121株(29.1%),凝固酶阴性葡萄球菌77株(18.5%),肺炎克雷伯菌29株(7.0%),金黄色葡萄球菌26株(6.3%),铜绿假单胞菌25株(6.0%)。葡萄球菌共检出108株,对万古霉素、利奈唑胺敏感率为100%,其中耐苯唑西林葡萄球菌68株(67.4%)。肠球菌对利奈唑胺敏感率均为100%。结论了解BSI的感染来源、分布特点,并进行长期耐药监测与防控,有助于更有效地治疗并降低病死率,加强抗菌药物管理,减少细菌耐药的产生。

Objective To investigate the species and drug resistance of blood stream infection （BSI） so as to provide evi- dence fur the clinical diagnosis and therapy. Methods The pathogenic bacterium species and sensibility of common antibacterials uf BSI from 2007 to 2011 in our hospital were retrospectively analyzed. Results A total of 416 （13.4%） strains were isolated irom 3107 doubtful blood specimens of BSI with hemocuhure from 2007 to 2011, and there were 229 strains （55.0%） of gram-negative baeilli, 180 strains （43.2%） of gram-positive cocci, 6 strains （1.4%） of fungus and 1 strain （0.2%） of anaerobion. The top five pathogenic bacteria were 121 strains （29.1%） of Escherichia coil, 77 strains （18.5%） of coagulase negative staphylococcus, 29 strains （7.0%） of Klebsiella pneumoniae, 26 strains （6.3%） of Staphylococcus aureus and 25 strains （6.0%） of Pseudomonas aenlgi- nosa in turn. A total of 108 strains of staphylococcus were isolated, and sensitive rates to vancomycin and linezolid were 100%, inclu- ding 68 strains （67.4%） of anti-oxacillin staphylococcus. The sensitive rate of enterococcus to linezolid was 100%. Conclusion Understanding of the infection sourees and distributed characteristics of BSI, long-term control, prevention and drug monitoring may effectively treat the disease, reduce mortality, strengthen management of antimicrobials and reduce the generation of bacterial resistance.