308 nm准分子光与窄谱中波紫外线治疗白癜风随机对照研究

A randomized comparative clinical trial of 308 nm monochromatic excimer light and 311 nm narrow-band ultraviolet in treating vitiligo

目的:观察308 nm准分子光与311 nm窄谱中波紫外线治疗白癜风的疗效及不良反应。方法:对288例白癜风患者采用随机、对照临床研究。患者随机分为两组,分别应用308 nm准分子光与311 nm窄谱中波紫外线进行照射治疗,每周2次,连续治疗30次,评价疗效及安全性。结果:308 nm准分子光组与311 nm窄谱中波紫外线组有效率分别为57.24%和46.15%,有效率比较差异有统计学意义(P<0.05)。不同年龄、病程、皮损类型、发病部位及临床分期对疗效有影响。结论:308 nm准分子光治疗白癜风疗效好,起效快,不良反应少。

Objective： To investigate the efficacy of 308 nm Monochromatic excimer light and 311 nm Narrow-band ultravio- let for the treatment of vitiligo and their side effects. Methods： A randomized comparative clinical trial was employed. Two hundred and eighty-eight patients with vitiligo were divided into 308 nm Monochromatic excimer light group and 311 nm Narrow-band ultraviolet group. Both groups were treated twice a week for 30 times. The therapeutic efficacy and safety were evaluated. Results： The total effective and markedly improvement rates for 308nm Monochromatic excimer light treated group were 88.28 % and 57.24% respectively, and for 311 nm Narrow-band ultraviolet treated group were 79.02% and 46.15% respectively. There were significant differences in the markedly improvement between the two groups （P〈 0.05）. But total ef fective rates were no significant differences between the two groups in （P 〈 0.05）. The therapeutic efficacy was significantly affected by ages of patients, disease duration, type of lesions, sites of lesions as well as clinical stages. Conclusion： 308 nm monochromatic excimer light is an effective modality for treating vitiligo with rapid acting and few adverse effects.