阿维A联合他克莫司治疗扁平苔藓-红斑狼疮重叠综合征

Treatment of lichen planus-lupus erythematosus overlap syndrome with acitretin and tacrolimus

报告阿维A联合他克莫司软膏封包治疗扁平苔藓-红斑狼疮重叠综合征1例。患者女,72岁。双足跟反复糜烂34年。皮肤科检查:双足跟水肿性红斑散在糜烂,皮损组织病理符合扁平苔藓组织病理表现。实验室检查:抗核抗体(ANA)(+),滴度1:80,均质型,抗双链DNA抗体(+),抗SS-A抗体(+),滴度1:4。诊断:扁平苔藓-红斑狼疮重叠综合征。给予口服阿维A30 mg/d,0.1%他克莫司软膏局部封包治疗,皮损好转明显。

A case of lichen planus-lupus erythematosus overlap syndrome treated with oral acitretin and tacrolimus occlusion is reported. A 72-year-old woman presented with recurrent erosions on her soles for 34 years. Skin examination showed ero- sions and edematous erythemas on both heels. Histological findings were consistent with lichen planus. Laboratory tests re- vealed a homogeneous pattern of ANA, with titer of 1 ： 80. Anti-dsDNA antibody was positive. Anti-SS-A antibody was pos- itive, with titer of 1 ： 4. The patient was diagnosed as lichen planus-lupus erythematosus overlap syndrome. Treatment with o- ral acitretin （30mg/d） and 0.1% tacrolimus occlusion was successful.