初诊2型糖尿病患者血纤维蛋白原水平相关影响因素的回归分析

Regression Analysis on Related Factors of Plasma Fibrinogen Level in Patients with Newly Diagnosed Type 2 Diabetes

目的:探讨初诊2型糖尿病(T2DM)患者血浆纤维蛋白原(FIB)水平相关影响因素。方法:收集67例2011年1月-2012年8月初诊的T2DM住院患者的临床资料,采用组间t检验和多重线性回归分析(Stepwise法,逐步法),回顾性分析患者血浆FIB与年龄、病程、血压、空腹静脉血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-CH)、高密度脂蛋白(HDL-CH)、空腹C肽(FCP)、糖化血红蛋白(HbA1c)、糖化血清蛋白(GSP)、血浆同型半胱氨酸(Hcy)、血尿酸(UA)、C反应蛋白(CRP)等之间的关系。结果:自变量UA进入回归分析模型(F=7.904,P=0.013),该回归模型有统计学意义,即血UA与血浆FIB存在线性依存关系[回归系数B=1.996,t=3.212,P=0.006,95%CI(0.672,3.321)],且为正相关(R=0.658,R2=0.432);其他自变量未进入回归模型(P>0.05)。结论:初诊T2DM患者血UA水平为血浆FIB水平的预测因子,控制血UA水平有利于降低血FIB水平。

Objective： To explore related factors of plasma fibrinogen （FIB） levels in the newly diagnosed type 2 diabetic patients.Methods： To select clinical data of hospitalized patients of 67 cases that newly diagnosed type 2 diabetes in our hospital from January 2011 to August 2012, and using t-tests and multiple linear regression analysis （step-by-step method）, retrospectively analyze relationship between plasma FIB and patient＇s age, disease duration, blood pressure, fasting blood glucose （FBG）, triglyceride（TG）, total cholesterol（TC）, I-ow-density（LDL-CH）, high-density lipoprotein（HDL-CH）, fasting C-peptide（FCP）, glycosylated hemoglobin（HbAlc） and glycosylated serum protein（GSP）, plasma homocysteine（Hcy）, serum uric acid（UA）, C-reactive protein （CRP）. Results ： In addition to the argument UA into the regression analysis model（F=7.904, P=0.013）, the regression model was statistically significant, the other independent variables did not enter the regression model, UA and FIB were linear dependenciesregression system B=1.996, t--3.212, P=0.006, 95%CI（0.672, 3.321）, and a positive correlation （R=0.658, R2=0.432）.Conclusion： Serum UA levels is the predictors of plasma FIB levels in newly diagnosed type 2 diabetic patients, controling blood UA levels can help to reduce the level of plasma FIB.