老年人微小病变性肾病综合征的激素治疗

Effect of Glucocorticoid on Minimal Change Nephritic Syndrome of Elderly

目的:探讨糖皮质激素对老年人微小病变性(minimal change,MC)特发性肾病综合征(PNS)的治疗作用。方法:采取开放对照研究,对10例老年人微小病变性肾病综合征,病程4周无好转的患者,给予大剂量标准疗程的强的松治疗,治疗结果与常规治疗组进行对比。结果:强的松组10例中,治疗2个月后7例获得完全缓解(70%),12个月后10例全部获得完全缓解(100%),常规治疗组10例中,在相对时间观察到的完全缓解人数分别为2例(20%)和5例(50%),两组间两个时期完全缓解率均有显著性差异(P<0.05)。结论:对老年人微小病变性肾病综合征,使用强的松治疗可以有效地减少蛋白尿,使患者早日达到完全缓解。

Objective： To explore the effect of glucocorticoid （GC） on the minimal change（MC） nephritic syndrome（NS） of elderly.Methods： An open, contrasted study was conducted.10 cases with NS of MS of elderly were divided into two groups, the one was treated with conventional therapy and the other with a large dose of prednisone based on conventional way.Results： The total number of entirely remission was 7 cases （70%）within two months and 10 cases （100%） within 12 months after treatment in prednisone group.Compare with 2 eases （20%） and 5 cases （50%） in control group, the difference of entirely remission rate was statistically significant.Conclusion： Prednisone is effective on the NS of MS of elderly.