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原癌基因Fra-1在胃癌组织中的表达及临床意义 被引量：1

Expression of Fra-1 and its clinical significance in gastric carcinoma tissues
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摘要 目的:探讨胃癌组织中Fra-1 mRNA的表达及临床意义。方法:收集50例胃癌标本及相关临床病理资料,以RT-PCR方法检测胃癌组织、癌旁正常组织中Fra-1 mRNA的表达情况。结果:Fra-1 mRNA在胃癌组织中的表达高于癌旁正常组织(P<0.01),而其表达在胃癌的淋巴结转移、浸润深度、TNM分期间差异均有统计学意义(P<0.05),而在患者的性别、年龄、肿瘤分化程度和大小间差异均无统计学意义(P>0.05)。结论:Fra-1的高表达可能与胃癌的发生及侵袭转移有关,可能成为胃癌早期诊断的分子指标及分子靶向治疗的新靶点。 Objective ：To investigate the clinical significance of Fra-1 expression in gastric carcinoma tissues. Methods：The clinieal and pathological data of 50 cases of gastric carcinoma were collected. The expression of Fra-1 in the gastric carcinoma tissues and the paraneoplastic tissues were detected using RT-PCR. Results：The expression of Fra-1 in gastric carcinoma tissues was higher than that in paraneoplastic tissues（P 〈0.01 ）. The expression of Fra-1 was related to the lymph node metastasis,depth of invasion and TNM stages （ P 〈 0.05 ）, but not related to the gender, age, cancer differentiation or size of the tumour（ P 〉 0.05 ）. Conclusions ： High expression of Fra-1 may be related to the genesis and progression of gastric carcinoma, it may act as a molecule parameter in the early diagnosis of gastric carcinoma and a potential target in the targeted therapy.
作者 王子安 陶言言 赵富友 毕国斌
机构地区 蚌埠医学院第一附属医院肿瘤内科 蚌埠医学院第一附属医院急诊内科 蚌埠医学院第二附属医院肿瘤内科
出处 《蚌埠医学院学报》 CAS 2013年第1期24-27,共4页 Journal of Bengbu Medical College
基金 安徽省教育厅自然科学基金资助项目(KJ2009B221Z)
关键词 胃肿瘤 Fra-1 反转录聚合酶链式反应 gastric carcinoma los related antigen-1 reverse transcription-poiymerase chain reaction
分类号 R735.2 [医药卫生—肿瘤]
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参考文献17

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共引文献6

同被引文献20

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蚌埠医学院学报
2013年 第1期

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