联合应用MRI多种功能成像诊断前列腺癌的研究

Preliminary study of the diagnosis of prostate cancer by the functional MRI

目的:探讨联合应用MRI多种功能成像(fMRI)技术在前列腺癌诊断与鉴别诊断中的价值。方法:收集并分析经手术、穿刺后病理或临床治疗后证实的50例前列腺病变患者的影像资料,均在常规扫描的基础上进行功能成像检查:包括扩散加权成像(DWI)、波谱及动态增强扫描。结果:前列腺癌在DWI图上多呈高信号,ADC图为低信号,ADC值平均低于(897.4±67.5)×10-6,波谱显示胆碱类化合物(Cho)峰值明显增高,枸橼酸盐(Cit)峰值减低,[Cho+肌酸(Cre)]/Cit比值升高,其平均值为2.75±0.83,动态增强为早期明显强化,时间强化曲线多为流出型或平台型。结论:联合应用fMRI检查可提高前列腺癌检出率,也有助于前列腺癌的定性,在临床上有较高的应用价值。

Objective ：To explore the value of diagnosis and differential diagnosis of prostate cancer by functional magnetic resonance imaging（fMRI）. Methods：The data of 50 cases with prostatic diseases, surgical pathology and the clinical treatment were analysed. All cases were checked by fMRI, diffusion weighted imaging （DWI） and spectrum and dynamic enhanced scanning on the basis of conventional scanning. Results：The DWI of prostate cancer were hyperintensities,its ADC map was low signal and the mean values of ADC were lower than （897.4 ± 67.5 ） × 10^- 6. The peak value of choline （Cho） increased and citrate （Cit） decreased were showed on spectrum, and the ratio of [ Cho ＋ creatine（ Cre）/Cit ] of the tumor tissue was increased, which was 2.75 ± 0.83. Dynamic increase in early period was obvious strengthening and tin]e-signal intensity curve of DCE-MRI was mainly the outflow type or terrace type. Conclusions ： The application of fMRI can improve the detection rates of prostate cancer and diagnosis, so it has high clinical value.