高血压患者健康子女血浆高敏C-反应蛋白、肿瘤坏死因子-α及白介素-6水平变化研究

Plasma levels of high sensitive C-Reactive protein,TNF-α and IL-6of healthy offspring with a family history of essential hypertention

目的检测具有高血压家族史的健康子女血浆高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及白介素-6(IL-6)水平变化,探讨其与高血压遗传的关系及在发病机制中的作用,为高血压的一级预防及治疗提供新的思路和方法。方法随机选择60例具有高血压家族史的健康子女为研究组,其中父母一方患高血压的30例为单亲组,父母双方均患高血压的30例为双亲组;父母双方均无高血压的健康子女30例为对照组。用酶联免疫吸附法(ELISA)测定血浆hs-CRP、TNF-α及IL-6的含量。结果研究组血浆中hs-CRP、TNF-α及IL-6含量均高于对照组,其中双亲组高于单亲组,单亲组高于对照组,差异有统计学意义(P<0.05)。结论具有高血压家族史的健康子女受遗传因素的影响,血浆炎性因子(hs-CRP、TNF-α及IL-6)升高,炎症反应可能是高血压发病原因之一;发现血浆hs-CRP、TNF-α及IL-6水平升高的具有高血压家族史的健康子女,可能是高血压的高危人群,应积极采取高血压一级预防措施进行干预。

To study the plasma levels of High sensitivity C-reactive protein,tumor necrosis factor-α and interleu kin-6 of healthy offspring with a family history of essential hypertension（EH）, and to explore the relationship of in- flammation reaction with pathogenesis of EH ,therefore try to find a new way of primary prevention and remedy/for es- sential hypertension. Methods Sixty healthy offspring with a family history of EH were randomly divided into two groups：30 offspring with one of the parents suffering from EH as group A;30 with both parents suffering from EH as group I3. Another 30 healthy offspring whose parents neither suffer from EH were assigned as control group. The pins ma level of high-sensitivity C-reactive protein, tumor necrosis factor-aand interleukin 6 were all determined by enzyme linked immunosorbent assay （ELISA）. Results The plasm level of hs-CRP,TNF-α and IL 6 were significantly higher in groups A and B than that in the control group. Plasma levels of hs-CRP,TNF-α and IL 6 were higher in group B than that in group A（P〈0.05）. Conclusion Due to heredity of EH,the plasma levels of hs CRP,TNF-α and IL-6 have in- creased before EH develops in the healthy offspring with a family history of EH, which suggest that inflammation might be a initiating agent for EH. Healthy offspring with a family history EH and with high plasma levels of hs-CRP,TNF-α and IL-6 are at high-risk to development of EH,therefore active prevention measures should be taken.