1-硝基芘和多环芳烃联合致突变性的研究

The Research on the joint mutagenicity of mixtures of 1-nitropyrene and nitro-PAHs

测定了 1 硝基芘 ( 1 NP)和其它 (硝基— )多环芳烃对Ames试验的 6个菌株 (TA98,TA1 0 0 ,YG1 0 2 1 ,YG1 0 2 4 ,YG1 0 2 6,YG1 0 2 9)的单一和联合致突变性 .1 ,6 二硝基芘 ( 1 ,6 DNP)、1 硝基芘 ( 1 NP)和 2 硝基芴 ( 2 NF)的单一致突变性都为阳性 ,且致突变性依次减弱 ;而其他PAHs样品均表现为阴性 .6种菌株对 ,1 ,6 DNP和 1 NP的敏感性依次为YG1 0 2 4 ,YG1 0 2 1 ,TA98,YG1 0 2 6,YG1 0 2 9,TA1 0 0 ;而它们对 2 NF的敏感性稍有差别 .联合致突变性实验结果表明共存的 1 ,6 DNP和 2 NF对 1 NP的致突变性有不同程度的增加 ,而共存的PAHs对 1 NP的致突变性却有不同程度的抑制作用 .

The mutagenicities of 1\|nitropyrene(1\|NP),2\|nitrofluorene(2\|NF),1,6\|dinitropyrene(1,6\|DNP),and five PAHs on Salmonella typhimurium TA98,TA100,YG1021,YG1024,YG1026,YG1029 were studied.The results showed that 1,6\|DNP is the most potent mutagen,next is 1\|NP and the last is 2\|NF;However,the mutagenicities of all PAHs tested are negative.The orders of sensitivity for six strains to both of 1\|NP and 1,6\|DNP is YG1024,YG1021,TA98,YG1026,YG1029,TA100,but it is not for 2\|NF.The results of the joint mutagenicity of the mixtures of 1\|NP and each of NO\-2\|PAHs showed that 2\|NF and 1,6\|DNP strengthened the mutagenicity of 1\|NP,but inhibited by every PAHs.