黄竹定痫胶囊对癫痫模型大鼠癫痫发作的影响

Influence of Huangzhu Dingxian Capsules on Epileptic Seizure of Epilepsy Model Rats

目的 :研究黄竹定痫胶囊对戊四唑(PTZ)点燃型癫痫大鼠癫痫发作的影响,探讨黄竹定痫胶囊抗癫痫作用机理。方法 :大剂量组灌服黄竹定痫胶囊6 mL,3次/d;小剂量组灌服黄竹定痫胶囊2 mL,3次/d;持续28 d。丙戊酸钠组灌服丙戊酸钠400 mg/kg,3次/d,连续28 d。正常对照组、模型对照组连续28 d灌服生理盐水,3次/d,1mL/次,持续28 d。观察癫痫大鼠体重、惊厥发作级别及持续时间的变化。结果 :PTZ点燃癫痫大鼠体重增加,惊厥发作级别降低,发作持续时间缩短。表明黄竹定痫胶囊具有良好的抗癫痫作用;而中药大剂量组与小剂量组比较有显著性差异,表明黄竹定痫胶囊抗癫痫的作用与剂量成正相关。结论 :黄竹定痫胶囊能显著抑制大鼠戊四唑点燃发作。

Objective ： To study the influence of Huangzhu Dingxian capsules on epileptic seizure of amyl tetrazolium （ PTZ ） -induced epilepsy rats, and to discuss its antiepileptic mechanism. Methods ： The high-dose group was given Huangzhu Dingxian capsules 6 mL, 3 times/day, and the small-dose group given Huangzhu Dingxian capsules 2 mL,3 times/day, continuously for 28 d. Valproie acid sodium group was given valproic acid sodium 400 mg/kg, 3 times/day, continuously for 28 d. Normal control group and model control group were given physiological saline, 3 times/d, 1 mL/time, continuously for 28 d. The body weight, seizure level and duration of change were observed. Results ： The weight gain and seizure level were reduced, and the attack last time was shortened. It showed that Huangzhu Dingxian capsules had good resistance to epilepsy action. The high-dose group and the small-dose group had significant differences in antiepileptic effect and dose-dependent manner. Couclt, sion：Huangzhu Diugxian capsules could significantly inhibit PTZ-induced epilepsy.