急性脑梗死TOAST病因分型与血浆纤维蛋白原的相关研究

Comparison of plasma fibrinogen level among stroke subtype according to TOAST criteria in patients with acute cerebral infarction

目的探讨急性脑梗死患者血浆纤维蛋白原(FIB)水平与脑梗死TOAST各亚型的关系。方法79例急性脑梗死患者按TOAST病因分型方法分类后,检测患者血浆纤维蛋白原浓度,比较病例组与对照组以及各亚型之间的血浆FIB水平。结果除其他原因引起的缺血性卒中(SOE)因例数少未作分析外,与对照组相比,脑梗死组各亚型中的FIB浓度增高均有显著意义;其中,FIB浓度在大动脉粥样硬化亚型(LAA)中的浓度最高,但与心源性亚型(CE)无明显差异,与腔隙性亚型(SAA)相比,两组均有显著意义。结论血浆FIB水平在脑梗死发生、发展过程中起重要作用,其中与LAA、CE型的发生关系更为密切。

Objective To investigate the association of plasma fibrinogen level with acute cerebral infarction （ACI） according to TOAST criteria. Methods The study included 79 cases with ACI （CI group ） which were classified according to TOAST criteria. The plasma fibrinogen level was measured by the Clause method. It compared the plasma fibrinogen level between the control group and case group and also subtypes of case group. Results The plasma fibrinogen level in patients with ACI were significantly higher than those in the controls. Meanwhile, the plasma fibrlnogen level were much higher in patients with subtype LAA and CE comparing those in subtype SAO. Conclusion High lasma fibrinogen level may be a risk factor for ACI. The level of plasma fibrinogen is higher in patients with ischemic eerebrovascular disease particularly for subtypes LAA and CE.