血管内皮功能检测在冠心病合并2型糖尿病的应用价值

Practical value of detection of vascular endothelial function in coronary heart disease with type 2 diabetes mellitus

目的:探讨血管内皮功能检测在冠心病合并2型糖尿病中的应用价值。方法:将研究对象分为合并2型糖尿病和不合并2型糖尿病的冠心病组,检测血管内皮依赖性舒张功能(FMD)、内皮素(ET)及一氧化氮(NO),并与冠脉造影结果对照。结果:合并2型糖尿病的冠心病组ET水平显著高于非糖尿病组(P<0.05),NO水平显著低于非糖尿病组(P<0.05);合并2型糖尿病的冠心病组FMD显著低于非糖尿病组(P<0.05)。结论:血管内皮功能检测可以作为诊断冠心病合并2型糖尿病的一项重要的辅助检查方法。

Objective： To study the practical value of detection of vascular endothelial function in coronary heart disease （CHD） with type 2 diabetes mellitus. Methods：The subjects were divided into coronary heart disease with and without diabetes melli- tus groups. Flow- mediated dilatation（ FMD）, Eudothelin （ET） and Nitric oxide （NO） were examined. The results of detection of vascular endothelial function were compared with that of coronary angiography. Results： The ET in diabetes mellitus group were signifi- cantly higher than CHD group; The NO in diabetes mellitus group were significantly lower than CHD group; The FMD in diabetes mel- litus group were significantly lower than CHD group. Conclusions： Detection of vascular endothelial function is an important method to the diagnosis of coronary heart disease with type2 diabetes mellitus.