铜绿假单胞菌注射液治疗恶性胸腔积液的临床观察

Clinical observation of PA-MSHA injection in the treatment of patients with malignant pleural effusion

目的观察铜绿假单胞菌注射液治疗恶性胸腔积液的有效性和不良反应。方法 53例恶性胸腔积液患者随机分组予B超定位下胸腔置管闭式引流术,经证实胸腔积液已基本排净后,27例治疗组胸腔注入铜绿假单胞菌注射液,26例对照组胸腔注入顺铂。结果治疗组有效率高于对照组(P<0.05)。毒副反应方面,治疗组除轻度发热及轻微胸痛外,其他不良反应明显少于对照组(P<0.05)。结论铜绿假单胞菌注射液胸腔注入治疗恶性胸腔积液安全有效。

Objective To evaluate the effectiveness and safety of PA-MSHA injection in the treatment of patients with malignant pleural effusion. Methods 53 patients with malignant pleural effusion were given closed drainage of pleural cavity, and then randomly di- vided into the treatment group （27 cases） and the control group （26 cases）. The treatment group received PA-MSHA injection through in- trathoracic infusion and the control group were treated with cisplatin through intrathoracic infusion. Results Compared to the control group, the response rate in the treatment group was better, and the statistical difference was significant （P 〈 0.05 ）. The incidence of side effects and toxicity was lower in the treatment group than in the control group （ P 〈 0.05 ）. Conclusion PA-MSHA injection through in- trathoracic infusion is an effective and safe therapeutic way in the treatment of malignant pleural effusion, thus it is worth to be promoted clinically.