肺癌患者胸水细胞块26例临床病理分析

Clinical pathology analysis of 26 lung adenocarcinoma patients with pleural fluid cell mass

目的探讨TTF-1在肺腺癌胸水细胞块中的表达及其意义。方法应用细胞块免疫细胞化学方法,检测26例肺腺癌胸水细胞块和20例间皮反应性增生中TTF-1的表达水平。结果 26例肺癌胸水中有19例TTF-1呈阳性表达,占73.08%,20例间皮反应性增生无一例呈阳性表达,两者TTF-1差异有统计学意义(χ2=24.90,P<0.01)。结论 TTF-1在胸水肺腺癌中表达具有较高特异性,有助于肺腺癌与胸水间皮反应性增生胸水的鉴别。

Objective To investigate the expression and its significance of TTF-1 in the pleural fluid cell mass of patients with lung adenocarcinoma. Methods. The expression of TTF-1 was detected by immunocytochemistry （ICC） in 26 cases of lung adenocarcinoma pleural effusion and 20 cases of mesothelial reactive hyperplasia. Results The positive rates of TTF-1 was 73.08% in patients with lung adenocarcinoma and 0% in patients with mesothelial reactive hyperplasia respectively, which showed a significant differences between the two groups （ X2 = 24. 90, P 〈 0. 01 ）. Conclusion TTF-1 is expressed with relatively high specificity in patients with pleural fluid lung adenocarcinoma, thus it can be used as an ancillary method for differentiating between lung adenocarcinoma pleural effusion and mesotheli- al reactive hyperplasia.