抗抑郁治疗对慢性阻塞性肺疾病患者生活质量及预后的影响

Curative effect of anti-depression on the quality of life and prognosis of patients with chronic obstructive pulmonary disease

目的观察抗抑郁治疗COPD合并抑郁患者生活质量及预后的影响。方法 COPD合并抑郁患者50例,分为治疗组和对照组。对照组给予COPD标准治疗,治疗组予COPD标准治疗联合抗抑郁治疗。对比两组治疗前后肺功能、圣乔治呼吸疾病问卷(SGRQ)评分、呼吸困难问卷(mMRC)分级;随访COPD急性加重再住院例次。结果两组治疗后肺功能均有改善(P<0.05),但组间差异无统计学意义;两组治疗后SGRQ评分、mMRC分级均有改善(P<0.05),治疗组差异更显著;再住院例次治疗组低于对照组(P<0.05)。结论抗抑郁治疗能改善COPD合并抑郁患者呼吸困难症状,进而改善患者生活质量及预后。

Objective To observe the effect of anti-depression treatment on quality of life and prognosis of the patients with chro- nic obstructive pulmonary disease （COPD） complicated with depression. Methods 50 COPD patients complicated with depression were randomly divided into two groups. The control group were given the standard treatment and the experiment group were given the standard treatment and anti-depression treatment. Lung function, SGRQ score and mMRC were compared between the two groups before and 1 -year after the treatment. Besides, the times of re-hospitalization were followed-up. Results The lung functions were all improved after the treatment, but there was no significant difference between the two groups. There was an obvious improvement in the SGRQ score and mMRC classication after the treatment between the two groups （ P 〈 0.05 ）. The times of re-hospitalization were less in the experiment group than in the control group （ P 〈 0.05 ）. Conclusion The anti-depresion treatment can improve the symptoms of dyspnea , and then improve the quality of life and prognosis of COPD patients complicated with depression.