慢阻肺患者血清中MMP-9、TIMP-1及ICAM-1的相关作用研究

Study of interaction of MMP-9,TIMP-1 and ICAM-1 in patients with COPD

目的研究COPD患者血清基质金属蛋白酶-9(MMP-9)抑制因子(TIMP-1)同细胞黏附因子-1(ICAM-1)、血管内皮黏附因子-1(VCAM-1)间的关系。方法 46例COPD患者和20例对照酶联免疫吸附法测量MMP-9,TIMP-1,ICAM-1及VCAM-1。结果 COPD组的MMP-9,TIMP-1,ICAM-1,VCAM-1显著高于对照组;MMP-9及TIMP-1均同ICAM-1,VCAM-1浓度呈正相关趋势(P<0.05);同时血清MMP-9,TIMP-1,ICAM-1,VCAM-1浓度同FEV1%,FEV1/FVC%呈负相关,MMP-9/TIMP-1比值同FEV1%,FEV1/FVC%呈负相关。结论 MMP-9,TIMP-1是造成COPD患者气流阻塞的重要因素。

Objective To study the interaction of serum MMP-9, TIMP-I and ICAM-I in patients with COPD. Methods The levels of MMP-9, TIMP-I and ICAM-1 in 46 cases of COPD patients and 20 cases of control people were tested by using enzyme linked im- munosorbent assay. Results The levels of MMP-9, TIMP-1, ICAM-1, VCAM-1 were significantly higher in the COPD group than those in the control group. The levels of MMP - 9 and TIMP - 1 were positively correlated with the levels of ICAM-I and VCAM-1. At the same time the levels of MMP-9, TIMP-1, ICAM-1, and VCAM-1 were negatively correlated with FEV1%, FEVI/FVC%. The ratio of MMP- 9/TIMP-1 was negatively correlated with FEV1% and FEVJFVC%. Conclusion MMP-9 and TIMP-1 are the important factors causing airflow obstruction in COPD patients.