1Rabe KF, Hurd S, Anzueto A,et al. Global Strategy for the diagno- sis, management, and prevention of COPD : GOLD executive summa- ry[J]. Am J Respir Crit Care Med,2007,176(6) :532 -555.
4[2]Beasley R.The Global Burden of Asthma Report,Global Initiative for Asthma(GINA)[EB/OL].[2006].http://www.ginasthma.org.
5[3]Johoson M.The beta 2nd receptor[J].Am J Respir Crit Care Med,1998,158:146-153.
6[4]Mak JC,Nishikawa M,Barnes PJ.Glucocorticosteroids increase beta 2-a-drenergic receptor transcription in human lung[J].Am J Physiol,1995,268:L41-L46.
7Maltais F, Hamilton A,Marciniuk D,et al.Improvements in symptom- limited exercise performance over 8 h with once-daily tiotropium in patients with COPD[J].Chest,2005,128(3): 1168-1178.
8Aaron SD,Vandemheen KL,Fergusson D,et al.Tiotropium in combination with lacebo,salmeterol,or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease:a randomized trial[J].Ann Intern Med,2007,146(8):545-555.
9Oostenb rink JB,Rutten- vanM olken MP, A1M I,et a.1 One- year cost- effectiveness of tiotropium versus ip ratropium to treat chronic obstructive pulmonary disease[J] .Eur Respir J,2004,23 (2) 241-249.
7Um S J, Lam S, Coxson H, et al. Budesonide/formoterol enhances the expression of pro surfactant protein-B in lungs of COPD patients [J]. PLoS One, 2013,8(12) :e83881.
8Holden NS, George T, Rider CF, et al. Induction of regulator of G-protein signaling 2 expression by long-acting 132-adrenoceptor ag- onists and glucocorticoids in human airway epithelial cells [ J ]. J Pharmacol Exp Ther, 2014,348 ( 1 ) : 12-24.
9Johns DP,Walters JA, Walters EH. Diagnosis and early detection of COPD using spirometry [ J ]. J Thorac Dis, 2014, 6 ( 11 ) : 1557 - 1569.
10Sanduzzi A, Balbo P, Candoli P, et al. COPD: adherence to therapy [ J]. Multidiscip Respir Med,2014,9( 1 ) :60.
