HPLC法比较不同给药方式对Graves病的疗效

COMPARISON OF THE THERAPEUTIC EFFECTS ON PATIENTS WITH GRAVES'DISEASE BETWEEN DIFFERENT MODES OF MEDICATION BY HPLC

目的 :为了比较不同给药方式对Graves’病的疗效。方法 :将 2 0例患有Graves’病的患者按治疗方式分为外敷组、口服组、手术组 3组〔前两组术前均以他巴唑 (MMI ,4 0mg/d)和氢化可的松 (HC ,4 0mg/d)治疗 7天以上〕。以HPLC比较了 3组患者甲状腺、血清中MMI及HC的含量。结果 :外敷组甲状腺中MMI及HC浓度均高于口服组 ,分别是后者的 1.17和 2 .64倍 ;外敷组血清中MMI及HC浓度均明显低于口服组。对 3组患者的疗效及副作用也同时进行了比较 ,结果外敷组的疗效明显高于口服组 ,且副作用较小。结论

Objective:To compare the therapeutic effects on patients with Graves'disease between different modes of medication.Methods:20 patients with Graves'disease were divided into three groups for treatment:top application,oral administration and operation (Both the first and second group were treated with methimazole (MMI 40mg/d) and hydrocortison (HC 40mg/d) for at least 7 days before operation).The concentration of MMI and HC in the serum and thyroid of patients in the three groups was compared by HPLC.Results:The concentration of MMI and HC in the thyroid of the first group of patients was 1.17 and 2.64 times higher than that of the second group while the concentration of MMI and HC in the serum of the patients in the first group was obviously lower than that of the second group.The effects and side-effects were also compared.The effect of medication by top application was better,with fewer side effects,than that of the oral administration of drugs.Conclusion:External application of drugs is an ideal mode of drug administration for Graves' disease.