一贯煎颗粒成型工艺的研究

Research on the Forming Techniques of Yi-Guan Decoction Granule

目的:优化一贯煎颗粒的成型工艺。方法:采用正交试验,以制粒难度、粒度分布、溶化性、每日服用量为指标,综合评价一贯煎颗粒成型工艺。结果:最佳成型工艺条件为:浸膏粉与微晶纤维素按7∶4混合均匀后,喷入用量为浸膏粉的4%的70%乙醇制软材。颗粒休止角32.45°,临界相对湿度约为72%。结论:该工艺为一贯煎颗粒的工业生产及环境控制提供了实验依据。

Objective： To find an optima] forming process of Yi-Guan Decoction granule. Methods： According to the diffi- culty of granu]ation, the size distrH3ution, daily dosage and solubility of the granule, the orthogon design was applied to eval- uate the process of the granule comprehensively, Results： The optimal process was that extract powder and mieroerystalline cellulose was mixed in proportion as 8：4 mixed with 70% of ethanol at 4% amount. The repose angle and CRH of the gran- ule were 32.45° and 72% respectively. Conclusion： The process provided an experimental evidence for industial production and environmental control of Yi-Guan Decoction granule.