高血压患者血液流变学及超敏C反应蛋白检测分析

Analysis of haemorheological indices and the level of high sensitive C-reactive protein on patients with hypertension

目的探讨原发性高血压患者血液流变学指标及超敏C反应蛋白(hs-CRP)水平变化及其相关性。方法分别测定130例原发性高血压患者、110例健康人的血液流变学指标、hs-CRP及血脂水平。结果原发性高血压患者高切变率、低切变率下的全血黏度、红细胞聚集指数、红细胞刚性指数等多项指标明显高于健康对照组,差异有统计学意义(P<0.05)。原发性高血压患者血清hs-CRP浓度明显高于健康对照组,差异有统计学意义(P<0.05)。结论原发性高血压患者常伴有血液流变学指标及hs-CRP水平异常,提示其血管壁存在炎性反应,与高血压发生发展存在相关性。

Objective To investigate correlation of haemorheological indices and the level of high-sensitive C-reactive protein in patients with essential hypertension.Methods Haemorheological indices and the levels of high-sensitive C reactive protein of 130 patients with hypertension（male 70,female60 cases） and 110 healthy people（male 60,female 50 cases） without hypertension were detected.Results Whole blood viscosity,erythrocyte aggregation index,erythrocyte rigidity index and other indices of patients with hypertension were higher than the control group in a high shear rate,low shear rate,differences were statistically significant（P0.01 or P0.05）.Serum hs-CRP concentration was significantly higher than that in normal controls（P0.05）.Conclusion Patients with hypertension are often accompanied with the abnormality of haemorheological indices and high-sensitive C-reactive protein levels in patients with essential hypertension vascular wall abnormalities,it suggest there is inflammation.It correlates with development of hypertension.