重症监护病房铜绿假单胞菌感染情况及耐药性分析

Clinical Distribution and drug-resistance of Pseudomonas aeruginosa infection in intensive care unit

目的探讨邵阳医学高等专科学校附属医院重症监护病房(ICU)铜绿假单胞菌感染情况及耐药状况,为临床合理使用抗菌药物治疗提供科学依据。方法采用回顾性方法统计分析205株铜绿假单胞菌感染情况及耐药状况。结果铜绿假单胞菌主要来源于痰液及咽拭子标本,占70.7%,其次是分泌物和血液,铜绿假单胞菌耐药现象严重,对多黏菌素B和头孢哌酮/舒巴坦均保持较好的敏感性,其次为阿米卡星、亚胺培南和哌拉西林/他唑巴坦,耐药率分别为17.6%、22.7%和28.1%;对其他抗菌药物的耐药率均大于55%。结论铜绿假单胞菌临床分离株多来自呼吸道,对多种抗菌药物的耐药率较高,多重耐药及泛耐药株不断出现,临床应加强ICU铜绿假单胞菌耐药性的监控,防止耐药菌株在医院内传播流行。

Objective To investigate clinical distribution and drug-resistance of Pseudomonas aeruginosa infection in intensive care unit（ICU）,and to guide clinical use of antibiotics.Methods The clinical datum of 205 cases of infection in ICU caused by Pseudomonas were retrospectively analyzed.Results Pseudomonas aeruginosa were mainly isolated from sputum（70.7%）,secretions and blood,drug-resistance status of Pseudomonas aeruginosa were very serious in local hospital,Pseudomonas kept highly susceptibility to polymyxin B and cefoperazone / Shubatan,Amikacin,imipenem and piperacillin / tazobactam,resistance rates were 17.6%,22.7% and 28.1%.Other antibiotic resistance rates were higher than 55%.Conclusion Clinical isolates of Pseudomonas aeruginosa are from the respiratory tract,drug resistance rates are high,multiple resistance and resistant strains emerged,it should strengthen the ICU monitoring of drug resistance of Pseudomonas aeruginosa,prevent drug-resistant strains in nosocomial transmission of epidemic.