摘要
目的观察以健脾益气、调肝解毒活血为治法组方的中药糖肝康对糖尿病脂肪肝模型大鼠血糖、血脂及肝脏中Ghrelin在免疫组化表达的影响。方法用腹腔注射STZ并给予12周高脂饮食后复制糖尿病脂肪肝大鼠模型,药物干预12周后,观察模型大鼠的血糖、血脂水平,及糖肝康对糖尿病脂肪肝大鼠血糖、血脂和肝脏中Ghrelin在免疫组化表达的影响。结果糖肝康可降低糖尿病脂肪肝模型大鼠的血糖血脂水平及肝脏中Ghrelin在免疫组化异常表达的水平。结论糖尿病脂肪肝的血糖、血脂水平可能与Ghrelin的表达水平相关,糖肝康可通过影响Ghrelin在免疫组化表达水平,在血糖、血脂水平等方面起到积极作用,值得进一步深入研究。
Objective Observe the effect on the btood glucose and lipid levels and immunohistochemical expression of Ghre-lin of Tanggankang in hver of diabetic fatty liver rat model. Methods Rat model were made with STZ and high-quality diet. After 12 weeks of drug intervention, the blood sugar, lipid, and the immunohistochemical expression of Ghrelin were observed. Results Tanggankang could not only lower the blood glucose and lipid levels, but also reduce the expression of Ghrelin. Conclusion The blood glucose and lipid level may be related to the expression of Ghrelin. Tanggankang may play an active role in glucose and lipid metabolism by affecting the expression of Ghrelin, and deserved further research.
出处
《中华全科医学》
2013年第2期168-170,F0003,共4页
Chinese Journal of General Practice
基金
山东省中医药科学技术研究项目(2011-038)
山东省科学技术厅科学技术发展计划项目(003130130)
