进展性缺血性脑卒中相关危险因素分析

Analysis of Related Risk Factors for Progressive Ischemic Stroke

目的探讨进展性缺血性脑卒中的危险因素。方法选取48例进展性缺血性脑卒中患者作为进展组,并选取同期住院的48例非进展性缺血性脑卒中患者作为对照,对两组患者的血压、血糖、同型半胱氨酸、颈动脉彩超进行分析。结果进展组与非进展组比较,两组高血压病史比较差异无统计学意义(P>0.05),发病后24 h内血压下降>30%后病情加重者,进展组有16例(33.3%),非进展组有3例(6.3%),两组间比较差异有统计学意义(P<0.05);进展组有高血糖者26例(54.2%),非进展组有11例(24.1%),两组间比较差异有统计学意义(P<0.05);进展组有高同型半胱氨酸血症者38例(79.1%),非进展组有12例(25.0%),两组间比较差异有统计学意义(P<0.05);有斑块形成且造成颈动脉中、重度狭窄,进展组有19例(76%),非进展组有8例(34.8%),两组间比较差异有统计学意义(P<0.05)。结论不合理降压、高血糖、高同型半胱氨酸、颈动脉不稳定斑块、颈动脉中重度狭窄是进展性缺血性脑卒中的危险因素。

Objective To explore the risk factors for progressive ischemic stroke. Methods 48 patients with progressive is-chemic stroke as progressing group were selected,48 patients with non-progressive ischemic stroke as non-progressing group. The blood pressure,glucose,homocysteine,and carotid duplex ultrasound in patients of the 2 groups were analyzed. Results There was no significant difference in the history of hypertension（P 〉 0.05） between the progressing group and non-progressing group, but sixteen（33.3% ） of the patients whose symptom were worse with the blood pressure decreased by 30% within 24 hours were in the progressing group and 3 （6.3%） were in the non-progressing group;the difference between the two groups was significant difference（ P 〈 0.05 ）. There were 26 patients（ 54.2% ） with hyperglucose in the progressing group and 11 （24.1% ） in the non- progressing group ; there was significant difference between the two groups （ P 〈 0.05 ）. 38 patients （ 79.1% ） with hyperhomocys- teinemia were in the progressing group, and 12 （25.0%） were in the non-progressing group;there was significant difference be- tween the two groups （P 〈 0.05 ）. In the progressing group, the carotid artery plaque accompanied severe stenosis was 19 （76%）, and 8 （34.8 % ） were in the non-progressing group;there was significant difference between the two groups （P 〈 0.05 ）. Conclu-sion Unreasonable lowering of blood pressure, hyperglucose, hyperhomocysteinemia, unstable plaques, and moderate severe ca- rotid stenosis were the risk factors for progressive ischemic stroke.