硫酸镁联合氨溴索治疗毛细支气管炎的临床疗效观察

Clinical Observation on the Efficacy of Magnesium Sulfate Combined Ambroxol in Treatment of Bronchitis

目的探讨静脉使用硫酸镁联合氨溴索治疗毛细支气管炎的临床效果。方法将126例毛细支气管炎患儿随机分为两组,治疗组与对照组各63例。两组均给予抗感染,雾化吸入沙丁胺醇、布地奈德平喘,全身使用激素抗炎,鼻导管吸氧等常规治疗。治疗组加用25%硫酸镁0.2 ml/(kg.d),3 h匀速静脉泵入;氨溴索每次30 mg,1次/d,静脉推注治疗。比较两组气喘改善时间、咳嗽减轻时间、肺部哮鸣音消失时间、住院时间和临床有效率。结果治疗组在气喘改善时间、咳嗽减轻时间、肺部哮鸣音消失时间、平均住院日均较对照组明显缩短,差异均有统计学意义(P<0.05)。治疗组治疗有效率96.82%,明显高于对照组的76.11%。结论硫酸镁联合氨溴索治疗毛细支气管炎安全有效,可减轻症状,缩短疗程,未见不良反应,适合基层医院使用。

Objective To explore the clinical effect of intravenous magnesium sulfate combined ambroxol in treatment of bronchitis. Methods 126 cases of children with bronchiolitis were randomly divided into two groups, the treatment group and the control group, with 63 eases in each group. The two groups were given anti-infective, nebulized albuterol asthma, budesonide, sys- temic steroid anti-inflammatory, nasal catheter oxygen and other conventional treatment. The treatment group was added with 25 % magnesium sulfate 0.2 ml/（ kg · d） 3 hours uniform venous pump;ambroxol 30 mg each time, 1 time/day intravenous injection treatment. Comparison of two groups of asthma, cough relieving time time, pulmonary wheezing disappearance time, duration of hospitalization and clinical efficiency were conducted. Results Asthma, cough relieving time, pulmonary wheezing disappeared, average hospitalization time was significantly shortened in treatment group, the differences were statistically significant （P 〈 0.05）. Treatment effective rate was 96. 82% Treatment group, which was significantly higher than that of control group （76.11% ）. Conclusion Magnesium sulfate combined with ambroxol hydrochloride in treatment of bronehiolitis was safe and ef-fective, which can alleviate the symptoms, shorten the course of treatment, there was no adverse reaction, which was suitable for nrimarv hosnitals.