阿立哌唑与喹硫平治疗老年期精神分裂症的对照研究

A Control Study of Aripiprazole and Quetiapine in Treatment of Senile Schizophrenic

目的比较阿立哌唑与喹硫平治疗老年期精神分裂症患者的疗效和安全性。方法将82例老年期精神分裂症患者随机分为两组,分别选用阿立哌唑或喹硫平治疗,疗程8周。采用阳性与阴性症状量表(PANSS)及治疗中出现的症状量表(TESS)评定疗效和不良反应,用世界卫生组织编制的生活质量量表(WHOQOL-100)评定生活质量。结果治疗8周后,阿立哌唑组显效率70.7%,有效率90.2%,喹硫平组显效率73.2%,有效率92.7%,两组疗效比较差异无统计学意义(P>0.05);阿立哌唑组WHOQOL-100各领域除精神支柱外均较治疗前明显改善,在生活领域、心理领域、独立领域、社会关系领域较喹硫平有显著改善;阿立哌唑组不良反应发生率与喹硫平组比较,两组差异无统计学意义(P>0.05)。结论阿立哌唑与喹硫平治疗老年期精神分裂症患者均有肯定疗效,安全性高。阿立哌唑组患者生活质量优于喹硫平组。

Objective To compare the efficacy and safety between aripiprazole and quetiapine in the treatment of senile schizophrenia. Methods A total of 82 patients with senile schizophrenia were randomly divided into two groups receiving aripi-prazole or quetiapine treatment. The periods of treatment in both groups were 8 weeks. The positive and negative symptom scale （PANSS） and treatment emergent symptom scale（TESS） were used to evaluate the efficacy and side effects, the quality of life was measured by World Health Organization quality of life questionnaire（WHOQOL-100）. Results The significant efficacy rate of aripiprazole group was 70.7% and the efficacy rate was 90.2% after 8 weeks,while 73.2% and 92.7% in quetiapine group. There were no statistical difference between two groups （P 〉 0.05 ）. Except item of psychic support, all item in WHOQOL-100 had a significant improvement in patients of aripiprazole group. Compared with quetiapine group, patients in aripiprazole group had marked improvement on those fields such as life, psychology,independence and social relationship. The incidence rate of adverse effect in aripiprazole group and that in quetiapine group, without statistical difference between them （ P 〉 0.05 ）. Conclusion Aripiprazole and quetiapine are effective and safe in the treatment of senile schizophrenia. The patients in aripiprazole group have a better quality of life than those in quetiapine group.