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cDNA基因芯片技术在骨肉瘤研究中应用 被引量:7

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摘要 骨肉瘤是严重危害儿童和青少年健康的一种骨原发性恶性肿瘤,研究骨肉瘤发生、发展、转移等相关基因,对其发病的分子生物学机制、早期诊疗和预后评估等方面有重要价值。cDNA基因芯片技术作为一种可平行、快速、敏感、高效检测正常组织与肿瘤组织基因差异的技术,现已广泛应用到骨肉瘤的研究中,本文就其在骨肉瘤研究中应用进展作一综述。
出处 《中华实用诊断与治疗杂志》 2013年第1期4-6,共3页 Journal of Chinese Practical Diagnosis and Therapy
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参考文献18

  • 1Bucher P. Regulatory elements and expression profiles[J]. Curt Opin Struct Bio1,1999,3(9) :400-407.
  • 2汝鸣,蔡郑东.基因芯片技术在骨肉瘤研究中的进展[J].中国骨肿瘤骨病,2007,6(2):99-101. 被引量:1
  • 3宋晓霞,孔令非.人乳头状瘤病毒分子生物学检测方法研究进展[J].中华实用诊断与治疗杂志,2012,26(5):419-420. 被引量:8
  • 4Pusztai L, Ayers M, Stec J, et al. Clinical application of cDNA microarrays in oncology[J]. Oncologist, 2003,3 (8) : 252-258.
  • 5Ouo Q M. DNA microarray and cancer[J]. Curr Opin Oncol,2003,15(1):36 -43.
  • 6Palmieri A, Pezzetti F, Brunelli G, etal. A comparison between genetic portraits of normal osteoblasts and osteosarcoma cell lines[J]. IndianJ Dent Res,2009,20(1):52-59.
  • 7Li G, Zeng H, Chen L, et al. An integrative multi-platform analysis for discovering biomarkers of osteosarcoma[J]. BMC Cancer, 2009,16(9) : 150.
  • 8王丹,赵炬才,吴凯彦,刘政国,张铁良.人骨肉瘤中P53基因表达的初步研究[J].河南诊断与治疗杂志,1997,11(3):129-131. 被引量:1
  • 9Zucchini C, Rocchi A, Manara M C, et al. Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell linesEJ~. Int J Oncol,2008,32(1):17 -31.
  • 10Chen X, Yang T T, Qiu X C, etal. Gene expression profiles of human osteosarcoma cell sublines with different pulmonary metastatic potentials[J]. Cancer Biol Ther, 2010,11 ( 2 ) :90- 95.

二级参考文献72

  • 1李国东,蔡郑东,陈正军,卢雪峰,雷会宁,郑龙坡.基因微矩阵技术在骨肉瘤发病相关基因研究中的应用[J].中华实验外科杂志,2005,22(9):1094-1097. 被引量:5
  • 2李新志,陈安民,郭风劲,罗正强.表达增强型绿色荧光蛋白的骨肉瘤细胞亚株建立及生物学特性[J].中华实验外科杂志,2006,23(9):1112-1114. 被引量:3
  • 3李晟磊,赵秋民,刘宗文,赵志华,高冬玲,郑湘予,陈奎生,张云汉.食管鳞癌中RECK和MMP-9蛋白表达的相关性及临床病理意义[J].世界华人消化杂志,2007,15(10):1082-1086. 被引量:34
  • 4翟德忠,黄强,朱卿,董军,霍红梅,兰青.组织芯片/免疫组化检测CDC2/CyclinB1在胶质瘤中的联合表达及意义[J].中国肿瘤临床,2007,34(11):604-607. 被引量:7
  • 5wAza-Blane P, Cooper CL, Wagner K, Batalov S, Oeveraux QL, Cooke MP. Identication of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening[J]. Mol Cell, 2003, 12 (3) : 627-637.
  • 6Shimada Y, Sato F, Shimizu K, Tsujimoto G, Tsukada K. cDNA microarray analysis of esophageal cancer: discoveries and prospects [J]. Gen Thorae Cardiovasc Surg, 2009, 57 (7) : 347-356.
  • 7Lisle JW, Choi JY, Horton JA, Allen M J, Damron TA. Metastatic osteosarcoma gene expression differs in vitro and in vivo [ J]. Clin Orthop Relat Res, 2008, 466 (9) : 2071-2080.
  • 8Strandh M, Johansson T, Lofstedt C. Global transcriptional analysis of pheromone biosynthesis-related genes in the female turnip moth, Agrotis segetum (Noctuidae) using a custom-made cDNA microarray [J]. Insect Biochem Mol Biol, 2009, 39 (7) : 484- 489.
  • 9Zwerner JP, Guimbellot J, May WA. EWS/FLI function varies in different cellular backgrounds [J].Exp Cell Res, 2003, 290 (2) : 414-419.
  • 10Riggi N, Cironi L, Provero P, Suva ML, Kaloulis K, Garcia-Echeverria C, et al. Development of Ewingg sarcoma from primary bone marrow-derived mesenchymal progenitor cells [ J ]. Cancer Res, 2005, 65 (24) :11459-11468.

共引文献16

同被引文献64

  • 1杨湘越.骨肉瘤实验室诊断研究现状及对策[J].中华临床医师杂志(电子版),2012,6(21):6841-6842. 被引量:8
  • 2付立平,包迎伟,巫智强,叶月霞,龚向阳.成年人骨肉瘤的临床及影像学特点(附33例分析)[J].放射学实践,2007,22(3):282-285. 被引量:7
  • 3Udd B, Krahe R. The myotonic dystrophies: molecular, clinical, and therapeutic challenges[J]. Lancet Neurol, 2012,11 (10):891- 905.
  • 4Mahadevan M S. Myotonie dystrophy: is a narrow focus obscuring the rest of the field[J]. Curr Opin Neurol, 2012, 25 (5) :609-613.
  • 5Udd B, Meola G, Krahe R, et al. Myotonic dystrophy type 2 (DM2) and related disorders report of the 180th ENMC workshop including guidelines on diagnostics and management 3- 5 December 2010, Naarden, the Netherlands[J]. Neuromuscul Disord,2011,21(6) :443-450.
  • 6Vihola A, Bachinski L L, Sirito M, et al. Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2 [J]. Acta Neuropatho, 2010,119(4) :465 -479.
  • 7Todd P K, Paulson H L. RNA mediated neurodegeneration in repeat expansion disorders[J]. Ann Neurol, 2010,67(3):291- 300.
  • 8Sobczak K, Wheeler T M, Wang W, et al. RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy [J]. MolTher,2013,21(2):380-387.
  • 9Chen W, Wang Y, Abe Y, etal. Haploinsuffciency for Znf9 in Znf9 +/- mice is associated with multiorgan abnormalities resembling myotonic dystrophy[J]. J Mol Biol, 2007,368 ( 1 ):8- 17.
  • 10Raheem O, Olufemi S, gachinski L, et al. Mutant (CCTG)n expansion causes abnormal expression of ZNF9 in myotonic dystrophy type2 (DM2)[J]. Am J Pathol,2010,177(6):3025- 3036.

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