1型糖尿病患者对氧磷酶1活性和氧化低密度脂蛋白水平变化

Changes of serum paraoxonase 1 activity and oxidative low-density lipoprotein level in patients with type 1 diabetes mellitus

目的观察1型糖尿病(type 1diabetes mellitus,T1DM)患者血清对氧磷酶1(paraoxonase 1,PON1)活性和氧化低密度脂蛋白(oxidative low-density lipoprotein,ox-LDL)水平的变化。方法 51例T1DM患者(T1DM组)分为有并发症组36例和无并发症组15例,45例体检健康者对照组,测定各组血清PON1活性、ox-LDL及血生化水平,并分析其相关性。结果 T1DM组血清PON1活性低于对照组(P<0.01),ox-LDL水平高于对照组(P<0.01);有并发症组血清PON1活性低于无并发症组(P<0.01),ox-LDL和三酰甘油水平高于无并发症组(P<0.05);血清PON1活性和ox-LDL水平呈负相关(r=-0.3660,P<0.01)。结论血清PON1活性和ox-LDL水平变化对阐述T1DM的发病机制,预防T1DM并发症的发生有重要意义。

Objective To evaluate paraoxonase 1 （PON1） activity and oxidative low-density lipoprotein （ox-LDL） level in patients with type 1 diabetes mellitus （TIDM）. Methods Fifty-one patients with TIDM （36 cases with complications and 15 cases without complications） and forty-five healthy controls were detected serum PON1 activity and ox -LDL level, and analyzed their correlation. Results Serum PON1 activity was lower and ox-LDL level was higher in patients with TIDM than that in healthy controls （P〈0.01）. PON1 activity was lower in TIDM patients with complications than that in TIDM patients without complications, and ox-LDL and triacylglycerol levels were higher in T1DM patients with complication than those in patients without complications （P〈0.05）. Serum PON1 activity was negatively correlated with ox-LDL level （r=-0. 3660, P〈0.01）. Conclusion Evaluation of PON1 activity and ox-LDL level plays an important role in the research of the mechanism of T1DM and the prevention of T1DM complications.