摘要
CD4 T cells play central roles in both immune response and regulation.They can either serve as the mediators of adaptive immune response against infections, or act as gate keepers to maintain immune homeostasis. Upon activation by antigens, naive T cells proliferate and differentiate into different T helper （Th） cells with distinct effector functions. Thl cells, induced by tran- scription factor T-bet and produce interferon- y, are crucial for clearing intracellular patho- gens. In contrast, IL-4 expressing Th2 cells driven by GATA-3 are responsible for the clearing of extraceUular pathogens. Thl7 cells, an additional subset ofT cells expressing tran- scription factor RORyt and cytokine ILl 7, are considered as the main drivers of autoimmune tissue injury.
CD4 T cells play central roles in both immune response and regulation.They can either serve as the mediators of adaptive immune response against infections, or act as gate keepers to maintain immune homeostasis. Upon activation by antigens, naive T cells proliferate and differentiate into different T helper （Th） cells with distinct effector functions. Thl cells, induced by tran- scription factor T-bet and produce interferon- y, are crucial for clearing intracellular patho- gens. In contrast, IL-4 expressing Th2 cells driven by GATA-3 are responsible for the clearing of extraceUular pathogens. Thl7 cells, an additional subset ofT cells expressing tran- scription factor RORyt and cytokine ILl 7, are considered as the main drivers of autoimmune tissue injury.
