摘要
As one of the facultatively intracellular bacteria, Salmonella enterica serovarTyphimurium （S. Typhimurium） replicates even in macrophages and induces their death--a key strategy of this virulent patho- gen in evading the innate immune response.1 The underlying mechanisms are well known but complex, because many pathways are involved, such as apoptosis,2 necrosis,3 pyr- optosis4 and autophagy,s In a recent issue of Nature Immunology, Robinson et al. reveal a novel pathway for killing macrophages dur- ing infection： type 1 interferon- （IFN-α and IFN-β associated necroptosis.6
As one of the facultatively intracellular bacteria, Salmonella enterica serovarTyphimurium （S. Typhimurium） replicates even in macrophages and induces their death--a key strategy of this virulent patho- gen in evading the innate immune response.1 The underlying mechanisms are well known but complex, because many pathways are involved, such as apoptosis,2 necrosis,3 pyr- optosis4 and autophagy,s In a recent issue of Nature Immunology, Robinson et al. reveal a novel pathway for killing macrophages dur- ing infection： type 1 interferon- （IFN-α and IFN-β associated necroptosis.6
