期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

中性粒细胞弹性蛋白酶在脑损伤中的作用机制 被引量：12

Mechanism of neutrophil elastase in brain injury
下载PDF
导出
摘要 炎症损伤在脑损伤中的重要作用逐渐受到重视。中性粒细胞弹性蛋白酶(neutrophil elastase,NE)是重要的炎症介质,可通过极强的蛋白水解作用参与脑损伤后的血脑屏障破坏,促进炎症细胞浸润,并与神经元的凋亡有一定的相关性。 Inflammatory damage in brain injury has been gradually recognized. Neutrophil elastase （NE）, as an important inflammatory mediator, is involved in the destruction of the blood-brain barrier after brain injury, promotes the infiltration of inflammatory cells, and correlates to neuronal apoptosis.
作者 凌海平 杭春华
机构地区 南方医科大学南京临床医学院(南京军区南京总医院)神经外科
出处 《医学研究生学报》 CAS 北大核心 2013年第1期73-76,共4页 Journal of Medical Postgraduates
基金 江苏省自然科学基金(BK2010459)
关键词 中性粒细胞弹性蛋白酶 脑损伤 血脑屏障 凋亡 Neutrophil elastase Brain injury Blood-brain barrier Apoptosis
分类号 R338 [医药卫生—人体生理学]
  • 相关文献

参考文献25

  • 1Faurschou M, Borregaard N. Neutrophil granules and secretory vesicles in inflammation[J]. Microbes Infect, 2003, 5(14):1317-1327.
  • 2Zimmer M, Medcalf RL, Fink TM, et al. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter[J]. Proc Natl Acad Sci USA, 1992, 89(17):8215-8219.
  • 3Liou TG, Campbell EJ. Nonisotropic enzyme-inhibitor interactions: a novel nonoxidative mechanism for quantum proteolysis by human neutrophils[J]. Biochemistry, 1995, 34(49):16171-16177.
  • 4Owen CA, Campbell EJ. Neutrophil proteinases and matrix degradation. The cell biology of pericellular proteolysis[J]. Semin Cell Biol, 1995, 6(6):367-376.
  • 5Korkmaz B, Moreau T, Gauthier F. Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions[J]. Biochimie, 2008, 90(2):227-242.
  • 6Meyer-Hoffert U. Neutrophil-derived serine proteases modulate innate immune responses[J]. Front Biosci, 2009,14(32):3409-3418.
  • 7Lee WL, Downey GP. Leukocyte elastase: physiological functions and role in acute lung injury[J]. Am J Respir Crit Care Med, 2001, 164(5):896-904.
  • 8Carroll TP, Greene CM, Taggart CC, et al. Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells[J]. J Immunol, 2005, 175(11):7594-7601.
  • 9Devaney JM, Greene CM, Taggart CC, et al. Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4[J]. FEBS Lett, 2003, 544(1-3):129-132.
  • 10Young RE, Thompson RD, Larbi KY, et al. Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo[J]. J Immunol, 2004, 172(7):4493-4502.

二级参考文献63

共引文献52

同被引文献137

引证文献12

二级引证文献53

医学研究生学报
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部