补肾法与活血法治疗兔膝骨关节炎的病理形态学对比研究

THE TREATMENT OF RABBIT OSTEOARTHRITIS OF THE KNEE BY KIDNEY REINFORCING AND BLOOD CIRCULATION ACTIVATING METHODS: A Comparative Study of Pathomorphology

通过观察纯补肾中药与活血中药对兔膝骨关节炎模型的软骨及滑膜的影响 ,以探讨补肾法与活血法的疗效与骨关节炎发病时间是否有关。以兔膝关节腔内注入木瓜蛋白酶造成骨关节炎模型 ,分别用补肾中药 ,活血中药灌胃治疗。造模 6周及 10周后取材作光镜及透射电镜下观察。结果示 6周后活血组的滑膜损伤程度较补肾组低 (P<0 .0 5 ) ,而 10周后补肾组的软骨破坏较活血组为轻 (P<0 .0 5 )。由此可认为在骨关节炎发病初期活血中药治疗作用较佳 ,随着病程进展 。

Luoyang Orthopedic Traumatologica Hospital and Institute of Henan Province, Luoyang 471002 [WT5”BZ]Rabbit models of osteoarthritis were made by injecting papain into rabbit knees and treated by transgastrically given kidneys reinforcing (KR) and blood circulation activating (BCA) traditional Chinese drugs, respectively, and the influence of the KR and BCA drugs on the cartilage and synovium of the models were observed as to explore whether the therapeutic effects of KR and BCA methods are related to the onset time of osteoarthritis or not. Six and ten weeks after the modelling, the specimens were taken and observed by optical and transmission electron microscopes. The results showed a lower synovium injury severity in BCA group 6 weeks after the modelling than that in KR group (P < 0.05) and a milder cartilage destruction in KR group 10 weeks after the modelling than that of BCA group (P < 0.05). From this it can be seen that BCA drugs have a better therapeutic effect at the early stage of osteoarthritis, while KR drugs have an advantage in the therapeutic effect with progress of the disease course.